PUBLICATIONS 2017

The studies developed in our Center are focused on understanding the basic principles of aging from molecules to systems. We’re also trying to decipher if the Chilean population harbors most of the genetic, molecular and cellular properties described in cohorts from all around the world or if it has unique characteristics.

 76 PUBLICATIONS

  • Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372, Coddou C., Sandoval R., Castro P., Lazcano P., Hevia M.J., Rokic M., Hall B., Terse A., Gonzalez-Billault C., Kulkarni A.B., Stojilkovic S.S. and Utreras E., Pain. 2017, 158 (2155-2168)
  • Aging and health policies in Chile: new agendas for research, Thumala D., Kennedy B.K., Calvo E., Gonzalez-Billault C., Zitko P., Lillo P., Villagra R., Ibáñez A., Assar R., Andrade M. and Slachevsky A, J. Health Systems & Reform. 2017, 3 (253-260)
  • Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth., Furusawa K., Asada A., Urrutia P., Gonzalez-Billault C., Fukuda M. and Hisanaga S.I., J. Neurosci. 2017, 37 (790-806)
  • Identity of the Purkinje cell cytoplasmic antibody type 2 autoantibody antigen is finally revealed, Gonzalez-Billault C., Ann Neurol. 2017, 81 (618-619)
  • Microtubule-regulating proteins and cAMP-dependent signaling in neuroblastoma differentiation, Muñoz-Llancao P., de Gregorio C., Las Heras M., Meinohl C., Noorman K., Boddeke E., Cheng X., Lezoualc’h F., Schmidt M. and Gonzalez-Billault C., Cytoskeleton. 2017, 74 (143-158)
  • Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia, Urrutia P.J., Hirsch E.C., González-Billault C. and Núñez M.T., J Neurochem. 2017, 142 (140-152)
  • From birth to death: A role for reactive oxygen species in neuronal development, Wilson C, Muñoz-Palma E, González-Billault C., Semin Cell Dev Biol. 2017,10.1016
  • Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target, Bustos, G., Cruz, P., Lovy, A., and Cárdenas C. Frontiers in Oncology. 2017, 7 (199)
  • The mitochondrial complex(I) ty of cancer, Urra1, FA., Muñoz, F., Lovy, A., Cárdenas2, C, Frontiers in Oncology. 2017, 7 (118)
  • Diabetic concentrations of Metformin inhibit platelet-mediated ovarian cancer cell progression, Erices1, R., Cubillos, S., Aravena, R., Santoro, F., Marquez, M., Orellana, R., Ramírez, C., González, P., Fuenzalida, P., Bravo, ML., Oliva, B., Kato, S., Ibañez, C., Brañes, J., Bravo, E., Alonso, C., García, K., Arab, C., Torres, VA., Godoy, A., Pereira, J., Bustos, G., Cardenas, C., Cuello, MA., and Owen2, GI, Oncotarget. 2017, 8 (20865-20880)
  • The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells, Schmeda-Hirschmann3, G., Gomez, CV., de Arias, AR., Burgos-Edwards, A., Alfonso J., Rolon, M., Brusquetti, F., Netto, F., Urra, FA., Cárdenas, C, J Ethnopharmacol. 2017, 199 (106–118)
  • Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells, Cataldo1, L., Mizgier, ML., Bravo, R., Jaña F., Cardenas, C., Llanos, P., Olmos PR., Galgani JE., Santos JL. and Cortés2 VA., PLOS One. 2017, 12 (e0170213)
  • Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase., Martin C, Leyton L, Hott M, Arancibia Y, Spichiger C, McNiven MA, Court FA, Concha MI, Burgos PV, Otth C., Front Cell Infect Microbiol. 2017
  • Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders, Salvadores N, Sanhueza M, Manque P, Court FA, Front Neurosci. 2017
  • Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model., Bargsted L, Medinas DB, Martínez Traub F, Rozas P, Muñoz N, Nassif M, Jerez C, Catenaccio A, Court FA, Hetz C, Matus S,  Scientific Reports. 2017
  • Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration, Catenaccio A, Llavero Hurtado M, Diaz P, Lamont DJ, Wishart TM, Court FA, Cell Death and Disease. 2017
  • ER stress in neurodegenerative disease: from disease mechanisms to therapeutic interventions, Felipe Cabral-Miranda, Claudio Hetz, De Gruyter Open. 2017, 4 (11-26)
  • The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics, Amado Carreras-Sureda, Philippe Pihán and Claudio Hetz, Frontiers in Oncology. 2017, 7 (article 55)
  • A Molecular Reporter for Monitoring Autophagic Flux in Nervous System In Vivo, K. Castillo V. Valenzuela, M. Oñate, C. Hetz, Methods Enzymol. 2017, 558 (109-131)
  • IRE1 signaling exacerbates Alzheimer’s disease pathogenesis, Claudia Duran-Aniotz, Victor Hugo Cornejo, Sandra Espinoza, Álvaro O. Ardiles, Danilo B. Medinas, Claudia Salazar, Andrew Foley, Ivana Gajardo, Peter Thielen, Takao Iwawaki, Wiep Scheper, Claudio Soto, Adrian G. Palacios, Jeroen J. M. Hoozeman, Claudio Hetz, Acta Neuropathol. 2017, 134 (489–506)
  • Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway, Alexis E. González, Vanessa C. Muñoz, Claudio Hetz, Viviana A. Cavieres, Hianara A. Bustamante, V́ıctor-Hugo Cornejo, Yunan C. Januario, Ibeth González, k Luis L. daSilva, Alejandro Rojas-Fernandez, Ronald T. Hay, Gonzalo A. Mardones, and Patricia V. Burgo, The Faseb Journal. 2017, 31 (1-14)
  • Prion Function and Pathophysiology in Non-Mammalian Models, N. Guerrero, M.M. Meynard, J. Borgonovo, K. Palma, M.L. Concha and C. Hetz, Bentham Science Publishers. 2017, 17 (13-23)
  • ER stress and the unfolded protein response in neurodegeneration, Claudio Hetz and Smita Saxena, Nature Reviews | Neurology. 2017, 13 (477-491)
  • Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis, Danilo B. Medinas, Jose V. González, Paulina Falcon and Claudio Hetz, Frontiers in Oncology. 2017, 10 (Article 216)
  • Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts, Gabriela Mercado and Claudio Hetz, Brain. 2017, 140 (1537-1547)
  • Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives, Joanna Obacz, Tony Avril, Pierre-Jean Le Reste, Hery Urra, Véronique Quillien, Claudio Hetz, Eric Chevet, Science Signaling. 2017, 10 (1-18)
  • The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo, Kyung-Won Park, Gyoung Eun Kim, Rodrigo Morales, Fabio Moda, Ines Moreno-Gonzalez, Luis Concha-Marambio, Amy S. Lee, Claudio Hetz & Claudio Soto, Scientific Reports. 2017, 7 (44723)
  • BCL-2 family: integrating stress responses at the ER to control cell demise, Philippe Pihán, Amado Carreras-Sureda and Claudio Hetz, Cell Death and Differentiation. 2017, 24 (1478-1487)
  • Proteostasis disturbance in amyotrophic lateral sclerosis, Danilo B. Medinas, Vicente Valenzuela and Claudio Hetz, Human Molecular Genetics. 2017, 26 (R91-R104)
  • Endoplasmic reticulum proteostasis impairment in aging, Martínez G., Duran-Aniotz C., Cabral-Miranda, Vivar JP. and Hetz C., Aging Cell. 2017, 4 (615-623)
  • Validación argentino-chilena de la versión en español del test Addenbrooke’s Cognitive Examination III para el diagnóstico de demencia, Bruno D, Slachevsky A, Fiorentino N, Rueda DS, Bruno G, Tagle AR, Olavarria L, Flores P, Lillo P, Roca M, Torralva T., Neurología. 2017,10.1016/j.nrl.2017.06.004
  • Dementia in Latin America: Epidemiological Evidence and Implications for Public Policy., Custodio N, Wheelock A, Thumala D, Slachevsky A., Frontiers in Aging Neuroscience. 2017, 9 (1-11)
  • Subjective memory complaints and cognitive decline, Andrea Slachevsky, Teresa Parrao, Patricia Lillo, Gonzalo Forno, Roque Villagra, Daniela Thumala, Helene Amieva, Pedro Zitko, Rodrigo Galvez, Rodrigo Assar, Elisabeth Wenk, Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. 2017, 13 (P806)
  • Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia., Sedeño L, Piguet O, Abrevaya S, Desmaras H, García-Cordero I, Baez S, Alethia de la Fuente L, Reyes P, Tu S, Mogilner S, Lori N, Landin-Romero R, Matallana D, Slachevsky A, Torralva T, Chialvo D, Kumfor F, García AM, Manes F, Hodges JR, Ibanez A, Hum Brain Mapp. 2017, 38 (3804-3822)
  • Neuroanatomical comparison of the “Word” and “Picture” versions of the Free and Cued Selective Reminding Test in Alzheimer’s disease. Short title: Neuroanatomical correlates of the Free and Cued Selective Reminding Test in Alzheimer’s disease, Slachevsky A; Barraza P; Hornberger M; Muñoz-Neira C; Flanagan E; Henriquez F; Bravo E; Farias M; Delgado C., Journal of Alzheimer’s Disease. 2017
  • Using game authoring platforms to develop screen-based simulated functional assessments in persons with executive dysfunction following traumatic brain injury, Slachevsky A; Martínez-Pernía, D, Núñez-Huasaf, J, del Blanco, A; Ruiz–Tagle A; Velazquez J; Gomez M; Blesius, CR; Ibañez A; Fernández-Manjón, Journal of Biomedical Informatics. 2017, 74 (71-84)
  • Cuestionario de actividades de la vida diaria (T-ADLQ): utilidad en pacientes con accidente cerebrovascular menor , Idiáquez J, Torres F, Madrid E, Vega J, Slachevsky A, Revista Medica de Chile. 2017, 145 (188 – 193)
  • The Cost of dementia in an unequal country: the case of Chile , Hojman DA ; Duarte F, Ruiz-Taglre J; Budnich M, Delgado C; Slachevsky A, Plos One. 2017, 12 (e0170213)
  • Tau Platelets correlates with regional brain atrophy in patients with Alzheimer’s disease , Slachevsky A, L Guzmán-Martínez, C. Delgado, P. Reyes, G. A. Farías, C Muñoz, E Bravo, M Farías, P Flores, C Garrido, James T Becker, O L López & R B. Maccioni, Journal of Alzheimer’s Disease. 2017, 55 (1595 – 1603)
  • So close yet so far: executive contribution to memory processing in behavioural variant frontotemporal dementia . , Bertoux M, Ramanan S, Slachevsky A, Wong S, Henriquez F, Musa G, Dubois B, Bottlaender M, Sarazin M, Hornberger M, Journal of Alzheimer’s Disease. 2017, 54 (1005 – 1014)
  • Geographical variation in dementia mortality in Italy, New Zealand, and Chile: the impact of latitude, vitamin D, and air pollution. (Running title: Dementia mortality in the Northern and Southern hemispheres Dementia), Russ T.C, Murianni L., Icaza G., Slachevsky A., Starr J.M., Dement Geriatr Cogn Disord. 2017, 42 (31 – 41)
  • Your perspective and my benefit: multiple lesion models of self-other integration strategies during social bargaining, Melloni M; Billete P; Baez S; Hesse E; de la Fuente L; Forno G; Birba A; García Cordero I; Serrano C, Plastino A; Slachevsky A; Huepe D; Sigman M; Manes F; García AM; S Ibáñez A, Brain. 2017, 139 (3022 – 3040), doi: 10.1093/brain/aww231
  • First symptoms and neurocognitive correlates of behavioral variant frontotemporal dementia, Santamaría-García H, Reyes P, Baéz S, García A, Martinez A, Santacruz JM,  Slachevsky A, Sigman M, Matallana D, Ibañez A., Journal of Alzheimer’s disease. 2017, 54 (957 – 970)
  • Percepción de conocimiento sobre las Demencias en Profesionales de la Salud de Chile (Chilean Health Professionals Perception of Knowledge about Dementia). Cartas al editor / Letter to the editor , Olavarría L, Mardones C, Delgado C, Slachevsky Ch A., Revista Medica de Chile. 2017, 144 (1365-1368)
  • Prion Function and Pathophysiology in Non-Mammalian Models, Guerrero, N.; M. Meynard, M.; Borgonovo, J.; Palma, K.; L. Concha, M.; Hetz, C., Current Molecular Medicine. 2017, 17 (13-23)
  • Gastrulation in an annual killifish: Molecular and cellular events during germ layer formation in Austrolebias, Pereiro, Luisa; Loosli, Felix; Fernández, Juan; Härtel, Steffen; Wittbrodt, Joachim; Concha, Miguel L., Developmental Dynamics. 2017, 246 (812-826)
  • Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish, Reig, Germán; Cerda, Mauricio; Sepúlveda, Néstor; Flores, Daniela; Castañeda, Victor; Tada, Masazumi; Härtel, Steffen; Concha, Miguel L., Nature Communications. 2017, 8 (15431)
  • Changes in neural circuitry associated with depression at pre-clinical, pre-motor and early motor phases of Parkinson’s disease, Borgonovo, Janina; Allende-Castro, Camilo; Laliena, Almudena; Guerrero, Néstor; Silva, Hernán; Concha, Miguel L., Parkinsonism & Related Disorders. 2017, 35 (17-24)
  • Genetic Diversity and Virulence Determinants of Escherichia coli Strains Isolated from Patients with Crohn’s Disease in Spain and Chile, Sandra Céspedes, Waleska Saitz, Felipe Del Canto, Marjorie De la Fuente, Rodrigo Quera, Marcela Hermoso, Raúl Muñoz, Daniel Ginard, Sam Khorrami, Jorge Giron, Rodrigo Assar, Ramón Rosselló-Mora, Roberto M Vidal, Frontiers in Microbiology. 2017, 8
  • Methotrexate pharmacogenetics in Uruguayan adults with hematological malignant diseases, Andrea Giletti, Marcelo Vital, Mariana Lorenzo, Patricia Cardozo, Gabriel Borelli, Raúl Gabus, Lem Martínez, Lilian Díaz, Rodrigo Assar, María Noel Rodriguez, Patricia Esperón, European Journal of Pharmaceutical Sciences. 2017, 109 (480-485)
  • Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment., Bocanegra Y, García AM, Lopera F, Pineda D, Baena A, Ospina P, Alzate D, Buriticá O, Moreno L, Ibáñez A, Cuetos F., Brain Lang. 2017, 168 (37-46)
  • An unaware agenda: interictal consciousness impairments in epileptic patients, Moguilner S,  García AM, Mikulan E, García MdC, Vaucheret E, Amarillo Y, Bekinschtein T, Ibáñez A, Neurosci Conscious. 2017,10.1093
  • Language deficits as a preclinical window into Parkinson’s disease: Evidence from asymptomatic parkin and dardarin mutation carriers, García AM, Sedeño L, Trujillo N, Bocanegra Y, Gomez D, Pineda D, Villegas A, Muñoz E, Arias W, Ibáñez A., J Int Neuropsychol Soc. 2017, 23 (150-158)
  • Rule reactivation and capture errors in goal directed behaviour., Roca M, García M , Torres Ardilla J , González Gadea ML , Torralva T, Ferrari J , Ibáñez A, Manes F, Duncan J., doi: Cortex. 2017,10.1016/j.cortex.2017.08.027
  • Locating Temporal Functional Dynamics of Visual Short-Term Memory Binding using Graph Modular Dirichlet Energy. , Smith K, Ricaud B, Shahid N, Rhodes S, Starr J, Ibanez A, Parra M, Escudero J, Vandergheynst P, Scientific Reports. 2017, 7 (42013)
  • Non-Invasive Brain Stimulation: A New Strategy in Mild Cognitive Impairment?, Birba A, Ibáñez A, Sedeño L, Ferrari J, García AM, Zimerman M., Front Aging Neurosci. 2017, 9 (Article 16)
  • Brain structural correlates of executive and social cognition profiles in behavioral variant frontotemporal dementia and elderly bipolar disorder., Baez S, Pinasco C, Roca M, Ferrari J, Couto B, García-Cordero I, Ibañez A, Cruz F, Reyes P, Matallana D, Manes F, Cetcovich M, Torralva T., Neuropsychologia. 2017,10.1016
  • A LesionProof Brain? Multidimensional Sensorimotor, Cognitive, and SocioAffective Preservation Despite Extensive  Damage in a Stroke Patient, García AM, Sedeño L, Herrera Murcia E, Couto B, Ibáñez A., Front Aging Neurosci. 2017, 8 (Article 335)
  • Action-semantic and syntactic deficits in subjects at risk for Huntington’s disease, García AM, Bocanegra Y, Herrera E, Pino M, Muñoz E, Sedeño L, Ibáñez A., J Neuropsychol. 2017,10.1111/
  • A core avenue for transcultural research on dementia: on the cross-linguistic generalization of language-related effects in Alzheimer’s disease and Parkinson’s disease., Calvo N, Ibáñez A, Muñoz E, García AM, Int J Geriatric Psychiatry. 2017,10.1002
  • The inner world of overactive monitoring: neural markers of interoception in obsessive-compulsive disorder, Yoris A, García AM, Traiber L, Santamaría-García H, Martorell M, Alifano F, Kichic R, Moser JS, Cetkovich M, Manes F, Ibáñez A, Sedeño L., Psychol Med. 2017, 47 (1957-1970)
  • Decision-making interventions to stop the global atrial fibrillation-related stroke tsunami, Cerasuolo JO, Montero-Odasso M, Ibañez A, Doocy S, Lip GY, Sposato LA., Int J Stroke. 2017, 12 (222-228)
  • Outcome-oriented moral evaluation in terrorists, Baez S, Herrera E, García AM, Manes F, Young L, Ibáñez A., Nature Human Behaviour. 2017, 1 (Article 118)
  • Time-order-errorsand duration ranges in the Episodic Temporal Generalization task, Mikulan E, Bruzzone M, Serodio M, Sigman M, Bekinschtein T, García AM, Sedeño L, Ibáñez A., Sci Rep. 2017, 7 (Article 2643)
  • Atypical Modulations of N170 Component during Emotional Processing and Their Links to Social Behaviors in Ex-combatants, Trujillo SP, Valencia S, Trujillo N, Ugarriza JE, Rodríguez MV, Rendón J, Pineda DA, López JD, Ibañez A, Parra MA., Front Hum Neurosci. 2017, 11 (Article 244)
  • Men, women…who cares? A population-based study on sex differences and gender roles in empathy and moral cognition, Baez S, Flichtentrei D, Prats M, Mastandueno R, García AM, Cetkovich M, Ibáñez A, PLoS One. 2017
  • Enhanced Working Memory Binding by Direct Electrical Stimulation of the Parietal Cortex, Birba A, Hesse E, Sedeño L, Mikulan EP, García MDC, Ávalos J, Adolfi F, Legaz A, Bekinschtein TA, Zimerman M, Parra M, García AM, Ibáñez A, Front Aging Neurosci. 2017, 9 (Article 178)
  • Attention, in and Out: Scalp-Level and Intracranial EEG Correlates of Interoception and Exteroception, García-Cordero I, Esteves S, Mikulan EP, Hesse E, Baglivo FH, Silva W, García MDC, Vaucheret E, Ciraolo C, García HS, Adolfi F, Pietto M, Herrera E, Legaz A, Manes F, García AM, Sigman M, Bekinschtein TA, Ibáñez A, Sedeño L., Front Neurosci. 2017, 11 (Article 411)
  • Corticostriatal signatures of schadenfreude: evidence from Huntington’s disease, Baez S, Pino M, Berrío M, Santamaría-García H, Sedeño L, García AM, Fittipaldi S, Ibáñez A.,J Neurol Neurosurg Psychiatry. 2017, 0 (1-5)
  • Brain information sharing during visual short-term memory binding yields a memory biomarker for familial Alzheimer’s disease, Parra MA, Mikulan E, Trujillo N, Sala SD, Lopera F, Manes F, Starr J, Ibanez A, Curr Alzheimer Res. 2017, 14 (1335-1347)
  • Empathy for others’ suffering and its mediators in mental health professionals, Santamaría-García H, Baez S, García AM, Flichtentrei D, Prats M, Mastandueno R, Sigman M, Matallana D, Cetkovich M, Ibáñez A., Sci Rep. 2017, 7 (Article 6391)
  • How Empathic are War Veterans? An Examination of the Psychological Impacts of Combat Exposure, Trujillo S, Trujillo N, Ugarriza JE, Uribe L, Pineda D, Aguirre D, Ibañez A, Decety J, Garcia-Barrera MA., Peace and Conflict: Journal of Peace Psychology. 2017, 23 (422-426)
  • A lesion model of envy and Schadenfreude: legal, deservingness and moral dimensions as revealed by neurodegeneration, Santamaría-García H, Baez S, Reyes P, Santamaría-García J, Santacruz-Escudero J, Matallana D, Arévalo A, Sigman M, García AM, Ibáñez A., Brain. 2017, 140 (3357-3377)
  • Parkinson’s disease compromises the appraisal of action meanings evoked by naturalistic texts, García AM, Bocanegra Y, Herrera E, Moreno L, Carmona J, Baena A, Lopera F, Pineda D, Melloni M, Legaz A, Muñoz E, Sedeño L, Baez S, Ibáñez A, Cortex. 2017,10.1016
  • The interplay between sharing behavior and beliefs about others in children during dictator games, Santamaría-García, H., González-Gadea ML, Di Tella R, Ibáñez A, Sigman M, Journal of Experimental Child Psychology. 2017, 166 (451-464)
  • Towards affordable biomarkers of frontotemporal dementia: A classification study via network’s information sharing, Dottori M, Sedeño L, Martorell Caro M, Alifano F, Hesse E, Mikulan E, García AM, Ruiz-Tagle A, Lillo P, Slachevsky A, Serrano C, Fraiman D, Ibanez A., Sci Rep. 2017, 7 (253-260)