The studies developed in our Center are focused on understanding the basic principles of aging from molecules to systems. We’re also trying to decipher if the Chilean population harbors most of the genetic, molecular and cellular properties described in cohorts from all around the world or if it has unique characteristics.


  • Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis., Beltran, S., Nassif, M., Vicencio, E., Arcos, J., Labrador, L., Cortes, B., Cortez, C., Bergmann, C., Espinoza, S., Hernandez, M., Matamala, J., Bargsted, L., Matus, S., Rojas-Rivera, D., Bertrand, M., Medinas, D., Hetz, C., Manque, P. and Woehlbier, U., Molecular Neurodegeneration. 2019, 14(1)., doi: 10.1186/s13024-019-0313-9
  • Predictors of unmet needs in Chilean older people with dementia: a cross-sectional study., Tapia Muñoz T, Slachevsky A, León-Campos MO, Madrid M, Caqueo-Urízar A, Rohde GC, Miranda-Castillo C., BMC Geriatr. 2019 Apr 15;19(1):106., doi: 10.1186/s12877-019-1131-1
  • Nutrient Sensing and Redox Balance: GCN2 as a New Integrator in Aging., Falcón, P., Escandón, M., Brito, Á. and Matus, S., Oxidative Medicine and Cellular Longevity, 2019, pp.1-9., doi: 10.1155/2019/5730532
  • The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish., Stanic, K., Reig, G., Wichmann, I., Opazo, J., Owen, G., Corvalán, A., Concha, M. and Amigo, J., Scientific Reports, 9(1)., doi: 10.1038/s41598-019-43436-8
  • Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics., Carreras-Sureda, A., Jaña, F., Urra, H., Durand, S., Mortenson, D., Sagredo, A., Bustos, G., Hazari, Y., Ramos-Fernández, E., Sassano, M., Pihán, P., van Vliet, A., González-Quiroz, M., Torres, A., Tapia-Rojas, C., Kerkhofs, M., Vicente, R., Kaufman, R., Inestrosa, N., Gonzalez-Billault, C., Wiseman, R., Agostinis, P., Bultynck, G., Court, F., Kroemer, G., Cárdenas, J. and Hetz, C., Nature Cell Biology. 2019, 21(6), pp.755-767., doi: 10.1038/s41556-019-0329-y
  • Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion., Limia, C., Sauzay, C., Urra, H., Hetz, C., Chevet, E. and Avril, T., Cancers. 2019, 11(5), p.631., doi: 10.3390/cancers11050631
  • Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models., Bodaleo F, Tapia-Monsalves C, Cea-Del Rio C, Gonzalez-Billault C, Nunez-Parra A., Front Mol Neurosci. 2019 May 28;12:135.,doi: 10.3389/fnmol.2019.00135
  • Axonal Degeneration Is Mediated by Necroptosis Activation., rrázola MS, Saquel C, Catalán RJ, Barrientos SA, Hernandez DE, Martínez NW, Catenaccio A, Court FA., Neurosci. 2019 May 15;39(20):3832-3844.,doi: 10.1523/JNEUROSCI.0881-18.2019
  • Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of daily living., Slachevsky A, Forno G, Barraza P, Mioshi E, Delgado C, Lillo P, Henriquez F, Bravo E, Farias M, Muñoz-Neira C, Ibañez A, Parra MA, Hornberger M., Neurol. 2019 Jun;266(6):1310-1322.,doi: 10.1007/s00415-019-09260-w. Epub 2019 Apr 4
  • β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation, Pinto, C., Medinas, D., Fuentes-Villalobos, F., Maripillán, J., Castro, A., Martínez, A., Osses, N., Hetz, C. and Henríquez, J., Neurobiology of Disease. 2019, 130, p.104497., doi: 10.1016/j.nbd.2019.104497
  • Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice., Kline RA, Dissanayake KN, Hurtado ML, Martínez NW, Ahl A, Mole AJ, Lamont DJ, Court FA, Ribchester RR, Wishart TM, Murray LM., Neurobiol Dis. 2019 Jun;130:104496.,doi: 10.1016/j.nbd.2019.104496.
  • Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders., Espinosa-Parrilla Y, Gonzalez-Billault C, Fuentes E, Palomo I, Alarcón M., Front Aging Neurosci. 2019 Jul 2;11:151.,doi: 10.3389/fnagi.2019.00151
  • Cell migration driven by substrate deformation gradients., Marquez, S., Reig Cardarella, G., Concha, M. and Soto, R., Physical Biology. 2019,doi: 10.1088/1478-3975/ab39c7
  • Pharmacological targeting of the unfolded protein response for disease intervention., Hetz, C., Axten, J. and Patterson, J., Nature Chemical Biology. 2019, 15(8), pp.764-775., doi: 10.1038/s41589-019-0326-2
  • Microtubule-Associated Proteins: Structuring the Cytoskeleton., Bodakuntla S, Jijumon AS, Villablanca C, Gonzalez-Billault C, Janke C., Trends Cell Biol. 2019 Aug 12. pii: S0962-8924(19)30120-5.,doi: 10.1016/j.tcb.2019.07.004
  • Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology., Arrazola MS, Court FA., Neural Regen Res. 2019 Aug;14(8):1385-1386.,doi: 10.4103/1673-5374.253520
  • Recommendations for the Nonpharmacological Treatment of Apathy in Brain Disorders., Manera V, Abrahams S, Agüera-Ortiz L, Bremond F, David R, Fairchild K, Gros A, Hanon C, Husain M, König A, Lockwood PL, Pino M, Radakovic R, Robert G, Slachevsky A, Stella F, Tribouillard A, Trimarchi PD, Verhey F, Yesavage J, Zeghari R, Robert P, Am J Geriatr Psychiatry. 2019 Aug 9. pii: S1064-7481(19)30459-2.,doi: 10.1016/j.jagp.2019.07.014
  • Small Molecules to Improve ER Proteostasis in Disease., Gonzalez-Teuber, V., Albert-Gasco, H., Auyeung, V., Papa, F., Mallucci, G. and Hetz, C., Trends in Pharmacological Sciences. 2019, 40(9), pp.684-695., doi: 10.1016/
  • The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability., Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP., Acta Neuropathol Commun. 2019 Sep 12;7(1):147.,doi: 10.1186/s40478-019-0802-7