PUBLICATIONS 2020

The studies developed in our Center are focused on understanding the basic principles of aging from molecules to systems. We’re also trying to decipher if the Chilean population harbors most of the genetic, molecular and cellular properties described in cohorts from all around the world or if it has unique characteristics.

42 PUBLICATIONS

  • Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease., Campos G, Schmidt-Heck W, De Smedt J, Widera A, Ghallab A, Pütter L, González D, Edlund K, Cadenas C, Marchan R, Guthke R, Verfaillie C, Hetz C, Sachinidis A, Braeuning A, Schwarz M, Weiß TS, Banhart BK, Hoek J, Vadigepalli R, Willy J, Stevens JL, Hay DC, Hengstler JG, Godoy P., Arch Toxicol. 2020 Jan;94(1):205-217.
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  • Emerging roles of the unfolded protein response (UPR) in the nervous system: A link with adaptive behavior to environmental stress?, Díaz-Hung ML, Martínez G, Hetz C., Int Rev Cell Mol Biol. 2020;350:29-61. Epub 2020 Jan 27.
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  • Autophagy in hepatic adaptation to stress., Hazari Y, Bravo-San Pedro JM, Hetz C, Galluzzi L, Kroemer G., Hazari Y, Bravo-San Pedro JM, Hetz C, Galluzzi L, Kroemer G.
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  • Alzheimer’s Disease or Behavioral Variant Frontotemporal Dementia? Review of Key Points Toward an Accurate Clinical and Neuropsychological Diagnosis., Musa G, Slachevsky A, Muñoz-Neira C, Méndez-Orellana C, Villagra R, González-Billault C, Ibáñez A, Hornberger M, Lillo P., J Alzheimers Dis. 2020;73(3):833-848
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  • Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons., Bodakuntla S, Schnitzler A, Villablanca C, Gonzalez-Billault C, Bieche I, Janke C, Magiera MM., J Cell Sci. 2020 Feb 13;133(3). pii: jcs241802.
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  • Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach., Bachli MB, Sedeño L, Ochab JK, Piguet O, Kumfor F, Reyes P, Torralva T, Roca M, Cardona JF, Campo CG, Herrera E, Slachevsky A, Matallana D, Manes F, García AM, Ibáñez A, Chialvo DR., Neuroimage. 2020 Mar;208:116456.
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  • Optimising adjacent membrane segmentation and parameterisation in multicellular aggregates by piecewise active contours, J. JARA‐WILDE I. CASTRO C.G. LEMUS K. PALMA F. VALDÉS V. CASTAÑEDA N. HITSCHFELD M.L. CONCHA S. HÄRTEL, J Microsc. 2020 May;278(2):59-75.
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  • Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease, Carolina Flores-Muñoz, Bárbara Gómez, Elena Mery, Paula Mujica, Ivana Gajardo, Claudio Córdova, Daniela Lopez-Espíndola, Claudia Durán-Aniotz, Claudio Hetz, Pablo Muñoz, Arlek M Gonzalez-Jamett, Álvaro O Ardiles, Front Cell Neurosci. 2020 Mar 19;14:46.
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  • Argentinian/Chilean validation of the Spanish-language version of Addenbrooke’s Cognitive Examination III for diagnosing dementia, D Bruno, A Slachevsky, N Fiorentino, D S Rueda, G Bruno, A R Tagle, L Olavarria, P Flores, P Lillo, M Roca, T Torralva, Neurologia. 2020 Mar;35(2):82-88.
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  • Argentinian/Chilean validation of the Spanish-language version of Addenbrooke’s Cognitive Examination III for diagnosing dementia, D Bruno, A Slachevsky, N Fiorentino, D S Rueda, G Bruno, A R Tagle, L Olavarria, P Flores, P Lillo, M Roca, T Torralva, Neurologia. 2020 Mar;35(2):82-88.
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  • Recommendations for the Nonpharmacological Treatment of Apathy in Brain Disorders., Valeria Manera, Sharon Abrahams, Luis Agüera-Ortiz, François Bremond, Renaud David, Kaci Fairchild, Auriane Gros, Cécile Hanon, Masud Husain, Alexandra König, Patricia L Lockwood, Maribel Pino, Ratko Radakovic, Gabriel Robert, Andrea Slachevsky, Florindo Stella, Anaïs Tribouillard, Pietro Davide Trimarchi, Frans Verhey, Jerome Yesavage, Radia Zeghari, Philippe Robert., The American Journal of Geriatric Psychiatry Volume 28, Issue 4, April 2020, Pages 410-420
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  • The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease, Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A Court, Cell Death Differ. 2020 Apr;27(4):1169-1185.
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  • Experiential Neurorehabilitation. A neurological therapy based on the enactive paradigm., Martínez-Pernía, D., Frontiers in Psychology, 11, 924.
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  • Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response., Estefanie Dufey, José Manuel Bravo-San Pedro, Cristian Eggers, Matías González-Quiroz, Hery Urra, Alfredo I Sagredo, Denisse Sepulveda, Philippe Pihán, Amado Carreras-Sureda, Younis Hazari, Eduardo A Sagredo, Daniela Gutierrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta-Alvear, Gisela Campos, Pedro M Domingos, Rémy Pedeux, Eric Chevet, Alejandra Alvarez, Patricio Godoy, Peter Walter, Alvaro Glavic, Guido Kroemer, Claudio Hetz, Nat Commun. 2020 May 14;11(1):2401.
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  • Metformin protects from oxaliplatin induced peripheral neuropathy in rats., N W Martinez, A Sánchez, P Diaz, R Broekhuizen, J Godoy, S Mondaca, A Catenaccio, P Macanas, B Nervi, M Calvo, F A Court. Neurobiol Pain. 2020 May 22;8:100048.
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  • Schwann Cell Reprogramming Into Repair Cells Increases miRNA-21 Expression in Exosomes Promoting Axonal Growth., Rodrigo López-Leal, Florencia Díaz-Viraqué, Romina J Catalán, Cristian Saquel, Anton Enright, Gregorio Iraola, Felipe Court. J Cell Sci. 2020 Jun 15;133(12):jcs239004.
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  • Ex Vivo Analysis of Axonal Degeneration Using Sciatic and Optic Nerve Preparations, Rodrigo López-Leal, Felipe Court. Methods Mol Biol. 2020;2143:179-189.
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  • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ transfer for survival, Cesar Cardenas, Alenka Lovy, Eduardo Silva-Pavez, Felix Urra, Craig Mizzoni, Ulises Ahumada-Castro, Galdo Bustos, Fabian Jaňa, Pablo Cruz, Paula Farias, Elizabeth Mendoza, Hernan Huerta, Paola Murgas, Martin Hunter, Melany Rios, Oscar Cerda, Irene Georgakoudi, Armen Zakarian, Jordi Molgó, and J. Kevin Foskett, Science Signaling 14 Jul 2020: Vol. 13, Issue 640, eaay1212
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  • Effects of spatial working memory in balance during dual tasking in traumatic brain injury and healthy controls, Ana Isabel Useros Olmo , Jose A. Periañez , David Martínez-Pernía & Juan Carlos Miangolarra Page, Brain Inj. 2020 Jul 28;34(9):1159-1167.
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  • Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates, Paula García-Huerta, Paulina Troncoso-Escudero, Di Wu, Arun Thiruvalluvan, Marisol Cisternas-Olmedo, Daniel R Henríquez, Lars Plate, Pedro Chana-Cuevas, Cristian Saquel, Peter Thielen, Kenneth A Longo, Brad J Geddes Gerardo Z Lederkremer, Neeraj Sharma, Marina Shenkman, Swati Naphade, S Pablo Sardi, Carlos Spichiger, Hans G Richter, Felipe A Court, Kizito Tshitoko Tshilenge, Lisa M Ellerby, R Luke Wiseman, Christian Gonzalez-Billault, Steven Bergink, Rene L Vidal, Claudio Hetz, Acta neuropathologica. 2020 Jul 8.
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  • Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease, Pablo Muñoz, Álvaro O Ardiles, Boris Pérez-Espinosa, Cristian Núñez-Espinosa, Andrea Paula-Lima, Christian González-Billault, Yolanda Espinosa-Parrilla, Mech Ageing Dev. 2020 Jul;189:111250.
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  • Geroscience in the Age of COVID-19, Nir Barzilai, James C Appleby, Steven N Austad, Ana Maria Cuervo, Matt Kaeberlein, Christian Gonzalez-Billault, Stephanie Lederman, Ilia Stambler, Felipe Sierra, Aging Dis. 2020 Jul 23;11(4):725-729.
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  • The UPRosome – decoding novel biological outputs of IRE1α function, Hery Urra, Philippe Pihán, Claudio Hetz., Journal of Cell Science, August 2020.
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  • Developmental Biology in Chile: historical perspectives and future challenges, Miguel L Concha, Iskra A Signore., The International journal of developmental biology, August 2020.
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  • A tale of turns and cycles guiding to neural crest migration. An Interview with Prof. Roberto Mayor, Miguel L Concha. Int J Dev Biol. 2020 Aug 20.
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  • Mechanisms, regulation and functions of the unfolded protein response, Claudio Hetz, Kezhong Zhang, Randal J Kaufman. Nature Reviews. Molecular Cell Biology, August 2020.
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  • Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response, María I. Díaz, Paula Díaz, Jimena Castillo Bennett, Hery Urra, Rina Ortiz, Pamela Contreras Orellana, Claudio Hetz and Andrew F. G. Cell Death & Disease, August 2020.
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  • Inside minds, beneath diseases: social cognition in amyotrophic lateral sclerosis-frontotemporal spectrum disorder, Patricia Lillo, Paulo Caramelli, Gada Musa, Teresa Parrao, Ricardo Hughes, Andres Aragon, Daniel Valenzuela, Gabriel Cea, Rafael Aranguiz, Henrique Cerqueira Guimarães, Laura Rousseff, Leandro Boson Gambogi, Luciano Inácio Mariano, Antônio Lúcio Teixeira, Andrea Slachevsky, Leonardo Cruz de Souza. J Neurol Neurosurg Psychiatry. 2020 Sep 22;jnnp-2020-324302.
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  • Fine-Tuning the TGFβ Signaling Pathway by SARA During Neuronal Development, Victoria Rozés-Salvador, Carlos Wilson, Cristina Olmos, Christian Gonzalez-Billault, Cecilia Conde. Front Cell Dev Biol. 2020 Sep 3;8:550267.
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  • Systematic Review of the Diagnostic Validity of Brief Cognitive Screenings for Early Dementia Detection in Spanish-Speaking Adults in Latin America, Nilton Custodio, Lissette Duque, Rosa Montesinos, Carlos Alva-Diaz, Martin Mellado, Andrea Slachevsky, Front Aging Neurosci. 2020 Sep 4;12:270.
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  • On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson’s and Huntington’s Disease, Paulina Troncoso-Escudero, Denisse Sepulveda, Rodrigo Pérez-Arancibia, Alejandra V Parra, Javiera Arcos, Felipe Grunenwald, Rene L Vidal, Front Aging Neurosci. 2020 Sep 3;12:571185.
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  • Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile, Dominique Lemaitre, Maica Llavero Hurtado, Cristian De Gregorio, Maritza Oñate, Gabriela Martínez, Alejandra Catenaccio, Thomas M Wishart, Felipe A Court, Mol Neurobiol. 2020 Oct;57(10):4232-4249.
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  • When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response, Matías González-Quiroz, Alice Blondel, Alfredo Sagredo, Claudio Hetz, Eric Chevet, Rémy Pedeux, Trends Cell Biol. 2020 Oct 6;S0962-8924(20)30171-9.
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  • When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response, Matías González-Quiroz, Alice Blondel, Alfredo Sagredo, Claudio Hetz, Eric Chevet, Rémy Pedeux, Trends Cell Biol. 2020 Oct 6;S0962-8924(20)30171-9.
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  • Mastering organismal aging through the endoplasmic reticulum proteostasis network, reticulum proteostasis network Rebecca C Taylor, Claudio Hetz, Aging Cell. 2020 Oct 31;e13265.
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  • The power of knowledge about dementia in Latin America across health professionals working on aging, Agustin Ibanez, Daniel Flichtentrei, Eugenia Hesse, Martin Dottori, Ailin Tomio, Andrea Slachevsky, Cecilia M Serrano, Christian Gonzalez-Billaut, Nilton Custodio, Claudia Miranda, Julian Bustin, Marcelo Cetckovitch 15, Fernando Torrente, Loreto Olavarria, Tomas Leon, Barbara Costa Beber, Sonia Bruki, Claudia K Suemoto, Ricardo Nitrini, Bruce L Miller, Jennifer S Yokoyama, Alzheimers Dement (Amst). 2020 Oct 14;12(1):e12117.
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  • Axonal Degeneration in AD: The Contribution of Aβ and Tau, Natalia Salvadores, Cristian Gerónimo-Olvera, Felipe A Court, Front Aging Neurosci. 2020 Oct 15;12:581767.
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  • Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates, Paula García-Huerta, Paulina Troncoso-Escudero, Di Wu, Arun Thiruvalluvan, Marisol Cisternas-Olmedo, Daniel R Henríquez, Lars Plate, Pedro Chana-Cuevas, Cristian Saquel, Peter Thielen, Kenneth A Longo, Brad J Geddes, Gerardo Z Lederkremer, Neeraj Sharma, Marina Shenkman, Swati Naphade, S Pablo Sardi, Carlos Spichiger, Hans G Richter, Felipe A Court, Kizito Tshitoko Tshilenge, Lisa M Ellerby, R Luke Wiseman, Christian Gonzalez-Billault, Steven Bergink, Rene L Vidal, Claudio Hetz, Acta Neuropathol. 2020 Nov;140(5):737-764.
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  • Getting intimate: Lysosomes and ER rendezvous to control autophagy, autophagyPhilippe Pihán, Claudio Hetz, Cell Calcium. 2020 Nov;91:102249.
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  • Alzheimer’s Disease or Behavioral Variant Frontotemporal Dementia? Review of Key Points Toward an Accurate Clinical and Neuropsychological Diagnosis, Gada Musa, Andrea Slachevsky, Carlos Muñoz-Neira, Carolina Méndez-Orellana, Roque Villagra, Christian González-Billault, Agustín Ibáñez, Michael Hornberger, Patricia Lillo, J Alzheimers Dis. 2020;73(3):833-848.
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  • GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly, Andrea Slachevsky, Pedro Zitko, David Martínez-Pernía, Gonzalo Forno, Felipe A Court, Patricia Lillo, Roque Villagra, Claudia Duran-Aniotz, Teresa Parrao, Rodrigo Assar, Paulina Orellana, Carolina Toledo, Rodrigo Rivera, Agustín Ibañez, Mario A Parra, Christian González-Billault, Helena Amieva, Daniela Thumala, BMC Geriatr. 2020 Nov 25;20(1):505.
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  • The impact of SARS-CoV-2 in dementia across Latin America: A call for an urgent regional plan and coordinated response, Agustin Ibanez, Hernando Santamaria-Garcia, Alejandra Guerrero Barragan, Alexander Kornhuber, Alyne Mendonca Marques Ton, Andrea Slachevsky, Antonio Lucio Teixeira, Beatriz Marcela Mar Meza, Cecilia M Serrano, Carlos Cano, Carolina Arias Gonzalez, Christian Gonzalez-Billault, Christopher Butler, Julian Bustin, Claudia Duran-Aniotz, Daisy Acosta, Diana L Matallana, Diego Acosta-Alvear, Dominic Trépel, Elisa De Paula França Resende, Fabricio Ferreira de Oliveira, Francisco Ibanez, Fernanda G De Felice, Gorka Navarrete, Ioannis Tarnanas, Irene B Meier, Jerusa Smid, Jorge Llibre-Guerra, Juan J Llibre-Rodriguez, Laís Fajersztajn, Leonel Tadao Takada, Lissette Duque, Maira Okada de Oliveira, Maria Aparecida Camargos Bicalho, María Isabel Behrens, Maritza Pintado-Caipa, Mario Parra, Maxwell Z Wilson, Myriam De La Cruz Puebla, Nilton Custodio, Rodrigo Santibanez, Rodrigo Bernardo Serafim, Ronnielly Melo Tavares, Stefanie Danielle Piña Escudero, Tomas Leon Rodriguez, Walter Dawson, Bruce L Miller, Kenneth S Kosik, Alzheimers Dement (N Y). 2020 Nov 23;6(1):e12092.
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