• 45 PUBLICATIONS

  DECEMBER 2023

  Consuelo Sepúlveda-Ibarra, Fernando Henríquez Chaparro , Anthony Marcotti , Guillermo Soto, Andrea Slachevsky Normalization of Rowland Universal Dementia Assessment Scale (RUDAS) in Chilean older people DOI: 10.1590/1980-5764-DN-2023-0033

  Maria Carolina Dalmasso, Itziar de Rojas, Natividad Olivar, Carolina Muchnik, Bárbara Angel, Sergio Gloger, Christian Gonzalez-Billault, Mercè Boada, Lluís Tàrraga, Andrea Slachevsky, Cecilia Albala … et al. The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer’s disease. DOI: 10.1002/alz.13522

  Amado Carreras-Sureda, Xin Zhang, Loann Laubry, Jessica Brunetti, Stéphane Koenig, Xiaoxia Wang, Cyril Castelbou, Claudio Hetz, Yong Liu, Maud Frieden , Nicolas Demaurex.The ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation. DOI: 10.1016/j.celrep.2023.113540

  Javiera Arcos, Felipe Grunenwald, Denisse Sepulveda, Carolina Jerez, Valentina Urbina, Tomas Huerta, Paulina Troncoso-Escudero, Daniel Tirado, Angela Perez, Rodrigo Diaz-Espinoza, Esteban Nova, Ulrich Kubitscheck, Juan Eduardo Rodriguez-Gatica, Claudio Hetz, Jorge Toledo , Pablo Ahumada, Diego Rojas-Rivera, Elisa Martín-Montañez, María Garcia-Fernandez, René L Vidal. IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson’s disease models. DOI: 10.1038/s41420-023-01734-1

  NOVEMBER 2023

  Fuentes-Flores A, Geronimo-Olvera C, Girardi K, Necuñir-Ibarra D, Patel SK, Bons J, Wright MC, Geschwind D, Hoke A, Gomez-Sanchez JA, Schilling B, Rebolledo DL, Campisi J, Court FA. Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury. EMBO Mol Med. 2023 Oct 20:e17907. doi: 10.15252/emmm.202317907. Epub ahead of print. PMID: 37860842.

  Ferrante FJ, Migeot J, Birba A, Amoruso L, Pérez G, Hesse E, Tagliazucchi E, Estienne C, Serrano C, Slachevsky A, Matallana D, Reyes P, Ibáñez A, Fittipaldi S, Campo CG, García AM. Multivariate word properties in fluency tasks reveal markers of Alzheimer’s dementia. Alzheimers Dement. 2023 Oct 12. doi: 10.1002/alz.13472. Epub ahead of print. PMID: 37823470.

  Cabral-Miranda F, Hetz C. Preventing brain aging by the artificial enforcement of the unfolded protein response: future directions. Neural Regen Res. 2024 Feb;19(2):393-394. doi: 10.4103/1673-5374.377608. PMID: 37488897; PMCID: PMC10503622.

  Vega-Galvez A, Gomez-Perez LS, Zepeda F, Vidal RL, Grunenwald F, Mejías N, Pasten A, Araya M, Ah-Hen KS. Assessment of Bio-Compounds Content, Antioxidant Activity, and Neuroprotective Effect of Red Cabbage (Brassica oleracea var. Capitata rubra) Processed by Convective Drying at Different Temperatures. Antioxidants (Basel). 2023 Sep 21;12(9):1789. doi: 10.3390/antiox12091789. PMID: 37760092; PMCID: PMC10526076.

SEPTEMBER 2023

Factors associated with healthy aging in Latin American populations. Hernando Santamaria-Garcia, Agustín Sainz-Ballesteros, Hernán Hernandez, Sebastian Moguilner, Marcelo Maito, Carolina Ochoa-Rosales, Michael Corley, Victor Valcour, J Jaime Miranda, Brian Lawlor, Agustín Ibáñez. Nat Med. 2023 Aug 10. DOI: 10.1038/s41591-023-02495-1

Software-guided (PREVEDEL) cognitive stimulation to prevent delirium in hospitalised older adults: study protocol. Maricel Garrido, Evelyn Álvarez, Felipe Salech, Verónica Rojas, Nicole Jara, José Ignacio Farías, Daniela Ponce de la Vega, Eduardo Tobar. BMC Geriatr. 2023 Aug 5. DOI: 10.1186/s12877-023-04189-2

AUGUST 2023

Expanded bioinformatic analysis of Oximouse dataset reveals key putative processes involved in brain aging and cognitive decline. Pamela J. Urrutia, Daniel A. Bórquez. Free Radic Biol Med. 2023 Jul 18
DOI: 10.1016/j.freeradbiomed.2023.07.0

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis. Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz-Hung ML, Tamburini G, Sabusap CMP, Gerakis Y, Cabral-Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, Quiroz G, Sardi P, Medinas DB, Contreras D, Piña R, Lourenco MV, Ribeiro FC, Ferreira ST, Rozas C, Morales B, Plate L, Gonzalez-Billault C, Palacios AG, Hetz C. Mol Ther. 2023 Jul 5
DOI: 10.1016/j.ymthe.2023.03.028

Calcium signaling in lysosome-dependent cell death. Mateus Milani, Philippe Pihán, Claudio Hetz. Cell Calcium. 2023 Jul
DOI: 10.1016/j.ceca.2023.102751

Intellectual cyborgs and the future of science. Agustín Ibáñez. Trends Cogn Sci. 2023 Jul 1
​​DOI: 10.1016/j.tics.2023.06.004

Harmonized multi-metric and multi-centric assessment of EEG source space connectivity for dementia characterization. Pavel Prado, Jhony A Mejía, Agustín Sainz-Ballesteros, Agustina Birba, Sebastian Moguilner, Rubén Herzog, Mónica Otero, Jhosmary Cuadros, Lucía Z-Rivera, Daniel Franco O’Byrne, Mario Parra, Agustín Ibáñez. Alzheimers Dement (Amst). 2023 Jul 8
DOI: 10.1002/dad2.12455

Sleep diplomacy: an approach to boosting global brain health. Diego A Golombek, Laura Booi, Dominic Campbell, Walter D Dawson, Harris Eyre, Brian Lawlor, Agustín Ibáñez. Lancet Healthy Longev. 2023 Jul 4
DOI: 10.1016/S2666-7568(23)00109-5

Association Between Neuroticism and Dementia on Healthcare Use: A Multi-Level Analysis Across 27 Countries from The Survey of Health, Ageing and Retirement in Europe (SHARE). Manuel Ruiz-Adame, Agustín Ibáñez, Tatyana Mollayeva, Dominic Trépel. J Alzheimers Dis. 2023 Jul 17 DOI: 10.3233/JAD-230265

VolumePeeler: a novel FIJI plugin for geometric tissue peeling to improve visualization and quantification of 3D image stacks. Gatica M, Navarro CF, Lavado A, Reig G, Pulgar E, Llanos P, Härtel S, Ravasio A, Bertocchi C, Concha ML, Cerda M. BMC Bioinformatics. 2023 Jul 12 DOI: 10.1186/s12859-023-05403-z

Iron regulatory protein 1: the deadly switch of ferroptosis. Bórquez, Daniel A.; Urrutia, Pamela J. Neural Regeneration Research ():, July 20, 2023. DOI: 10.4103/1673-5374.380889

JULY 2023

Heterogeneous factors influence social cognition across diverse settings in brain health and age-related diseases. Sol Fittipaldi, Agustina Legaz, Marcelo Maito, Hernan Hernandez, Florencia Altschuler, Veronica Canziani, Sebastian Moguilner, Claire Gillan, Josefina Castillo, Patricia Lillo, Nilton Custodio, José Avila-Funes, Juan Cardona, Andrea Slachevsky, Fernando Henriquez, Matias Fraile-Vazquez, Leonardo Cruz de Souza, Barbara Borroni, Michael Hornberger, Francisco Lopera, Hernando Santamaria-Garcia, Diana Matallana, Pablo Reyes, Cecilia Gonzalez-Campo, Maxime Bertoux, Agustín Ibáñez. Res Sq. 2023 Jun 9
DOI: 10.21203/rs.3.rs-3007086/v1

Can prosocial values improve brain health? Agustín Ibáñez, Diana Matallana, Bruce Miller. Front Neurol. 2023 Jun 5
DOI: 10.3389/fneur.2023.1202173

Assessing subjective cognitive decline in older adults attending primary health care centers: what question should be asked?. Matías Molina-Donoso, Teresa Parrao, Céline Meillon, Daniela Thumala, Patricia Lillo, Roque Villagra, Agustín Ibañez, Mauricio Cerda, Pedro Zitko, Hélène Amieva & Andrea Slachevsky (2023) Journal of Clinical and Experimental Neuropsychology, DOI: 10.1080/13803395.2023.2221399

Assessing subjective cognitive decline in older adults attending primary health care centers: what question should be asked?. Matías Molina-Donoso, Teresa Parrao, Céline Meillon, Daniela Thumala, Patricia Lillo, Roque Villagra, Agustín Ibañez, Mauricio Cerda, Pedro Zitko, Hélène Amieva & Andrea Slachevsky (2023) Journal of Clinical and Experimental Neuropsychology, 

JUNE 2023

Low-dimensional organization of global brain states of reduced consciousness. Yonatan Sanz Perl, Carla Pallavicini, Juan Piccinini, Athena Demertzi, Vincent Bonhomme, Charlotte Martial, Rajanikant Panda, Naji Alnagger, Jitka Annen, Olivia Gosseries, Agustín Ibáñez, Helmut Laufs, Jacobo D Sitt, Viktor K Jirsa, Morten L Kringelbach, Steven Laureys, Gustavo Deco, Enzo Tagliazucchi. Cell Rep. 2023 May 11 DOI: 10.1016/j.celrep.2023.112491

Social and moral psychology of COVID-19 across 69 countries. Azevedo F, Pavlović T, Rêgo GG, Ay FC, Gjoneska B, Etienne TW, Ross RM, Schönegger P, Riaño-Moreno JC, Cichocka A, Capraro V, Cian L, Longoni C, Chan HF, Van Bavel JJ, Sjåstad H, Nezlek JB, Alfano M, Gelfand MJ, Birtel MD, Cislak A, Lockwood PL, Abts K, Agadullina E, Aruta JJB, Besharati SN, Bor A, Choma BL, Crabtree CD, Cunningham WA, De K, Ejaz W, Elbaek CT, Findor A, Flichtentrei D, Franc R, Gruber J, Gualda E, Horiuchi Y, Huynh TLD, Ibanez A, Imran MA, Israelashvili J, Jasko K…Sci Data. 2023 May 11 DOI: 10.1038/s41597-023-02080-8

Country-level gender inequality is associated with structural differences in the brains of women and men. Zugman A, Alliende LM, Medel V, Bethlehem RAI, Seidlitz J, Ringlein G, Arango C, Arnatkevičiūtė A, Asmal L, Bellgrove M, Benegal V, Bernardo M, Billeke P, Bosch-Bayard J, Bressan R, Busatto GF, Castro MN, Chaim-Avancini T, Compte A, Costanzi M, Czepielewski L, Dazzan P, de la Fuente-Sandoval C, Di Forti M, Díaz-Caneja CM, María Díaz-Zuluaga A, Du Plessis S, Duran FLS, Fittipaldi S, Fornito A, Freimer NB, Gadelha A, Gama CS, Garani R, Garcia-Rizo C, González Campo C, Gonzalez-Valderrama A, Guinjoan S, Holla B, Ibañez A, Ivanovic D, Jackowski A, Leon-Ortiz P, Lochner C, López-Jaramillo C, Luckhoff H, Massuda R, McGuire P, Miyata J, Mizrahi R, Murray R, Ozerdem A, Pan PM, Parellada M, Phahladira L, Ramirez-Mahaluf JP, Reckziegel R, Reis Marques T, Reyes-Madrigal F, Roos A, Rosa P, Salum G, Scheffler F, Schumann G, Serpa M, Stein DJ, Tepper A, Tiego J, Ueno T, Undurraga J, Undurraga EA, Valdes-Sosa P, Valli I, Villarreal M, Winton-Brown TT, Yalin N, Zamorano F, Zanetti MV; cVEDA; Winkler AM, Pine DS, Evans-Lacko S, Crossley NA. Proc Natl Acad Sci U S A. 2023 May 16
DOI: 10.1073/pnas.2218782120

The “when” matters: Evidence from memory markers in the clinical continuum of Alzheimer’s disease. Gonzalo Forno, Mario A Parra, Daniela Thumala, Roque Villagra, Mauricio Cerda, Pedro Zitko, Agustín Ibañez, Patricia Lillo, Andrea Slachevsky. Neuropsychology. 2023 May 25. DOI: 10.1037/neu0000891

Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation. Macarena S Arrázola, Matías Lira, Felipe Véliz-Valverde, Gabriel Quiroz, Somya Iqbal, Samantha L Eaton, Douglas J Lamont, Hernán Huerta, Gonzalo Ureta, Sebastián Bernales, J César Cárdenas, Waldo Cerpa, Thomas M Wishart, Felipe A Court. Aging Cell. 2023 May;22 DOI: 10.1111/acel.13814

Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research. Alzheimer’s Dement. 2023; 1- 20. Sanne Franzen, Karen Nuytemans, Renelle Bourdage, Paulo Caramelli, Ratnavalli Ellajosyula, Elizabeth Finger, Ignacio Illán-Gala, Samantha M. Loi, Darby Morhardt, Yolande Pijnenburg, Katya Rascovsky, Monique M. Williams, Jennifer S. Yokoyama, Suvarna Alladi, Yavuz Ayhan, Iris Broce, Sheila Castro-Suarez, Kristy Coleman, Leonardo Cruz de Souza, Penny A. Dacks, Sterre C. M. de Boer, Jessica de Leon, Shana Dodge, Stephanie Grasso, Veer Gupta, Vivek Gupta, Nupur Ghoshal, Vidyulata Kamath, Fiona Kumfor, Jordi A. Matias-Guiu, Pauline Narme, T. Rune Nielsen, Daniel Okhuevbie, Stefanie D. Piña-Escudero, Ramiro Ruiz Garcia, Marta Scarioni, Andrea Slachevsky, Aida Suarez-Gonzalez, Boon Lead Tee, Elena Tsoy, Hülya Ulugut, Ganesh M. Babulal, Chiadi U. Onyike
DOI: 10.1002/alz.13129

MAY 2023

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis. Claudia Duran-Aniotz, Natalia Poblete, Catalina Rivera-Krstulovic, Álvaro O Ardiles, Mei Li Díaz-Hung, Giovanni Tamburini, Carleen Mae P Sabusap, Yannis Gerakis, Felipe Cabral-Miranda, Javier Diaz, Matias Fuentealba, Diego Arriagada, Ernesto Muñoz, Sandra Espinoza, Gabriela Martinez, Gabriel Quiroz, Pablo Sardi, Danilo B Medinas, Darwin Contreras, Ricardo Piña, Mychael V Lourenco, Felipe C Ribeiro, Sergio T Ferreira, Carlos Rozas, Bernardo Morales, Lars Plate, Christian Gonzalez-Billault, Adrian G Palacios, Claudio Hetz. Mol Ther. 2023 Apr. https://pubmed.ncbi.nlm.nih.gov/37016577/

Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses. Alejandro Acevedo, Felipe Torres, Miguel Kiwi, Felipe Baeza-Lehnert, L Felipe Barros, Dasfne Lee-Liu, Christian González-Billault. Aging (Albany NY). 2023 Apr. https://pubmed.ncbi.nlm.nih.gov/37074814/

Visual deep learning of unprocessed neuroimaging characterises dementia subtypes and generalises across non-stereotypic samples. Sebastian Moguilner, Robert Whelan, Hieab Adams, Victor Valcour, Enzo Tagliazucchi, Agustín Ibáñez. EBioMedicine. 2023 Apr. https://pubmed.ncbi.nlm.nih.gov/36972630/

Source space connectomics of neurodegeneration: One-metric approach does not fit all. Pavel Prado, Sebastian Moguilner, Jhony A Mejía, Agustín Sainz-Ballesteros, Mónica Otero, Agustina Birba, Hernando Santamaria-Garcia, Agustina Legaz, Sol Fittipaldi, Josephine Cruzat, Enzo Tagliazucchi, Mario Parra , Rubén Herzog, Agustín Ibáñez. Neurobiol Dis. 2023 Apr. https://pubmed.ncbi.nlm.nih.gov/36841423/

Are cytoskeleton changes observed in astrocytes functionally linked to aging?. Cristopher Villablanca, René Vidal, Christian Gonzalez-Billault. Brain Res Bull. 2023 May. https://pubmed.ncbi.nlm.nih.gov/36935053/

APRIL 2023

• Visual deep learning of unprocessed neuroimaging characterises dementia subtypes and generalises across non-stereotypic samples. Moguilner S, Whelan R, Adams H, Valcour V, Tagliazucchi E, Ibáñez A. EBioMedicine. 2023 Mar 25;90:104540. doi: 10.1016/j.ebiom.2023.104540.
• Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation. Arrázola MS, Lira M, Véliz-Valverde F, Quiroz G, Iqbal S, Eaton SL, Lamont DJ, Huerta H, Ureta G, Bernales S, Cárdenas JC, Cerpa W, Wishart TM, Court FA. Aging Cell.2023 Mar 27:e13814. doi: 10.1111/acel.13814.
• Are cytoskeleton changes observed in astrocytes functionally linked to aging?. Villablanca C, Vidal R, Gonzalez-Billault C. Brain Res Bull. 2023 Mar 17;196:59-67. doi: 10.1016/j.brainresbull.2023.03.007.
• A Role for Second Messengers in Axodendritic Neuronal Polarity. Urrutia PJ, González-Billault C. J Neurosci.2023 Mar 22;43(12):2037-2052. doi: 10.1523/JNEUROSCI.1065-19.2023.
• Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets. Tshilenge KT, Aguirre CG, Bons J, Gerencser AA, Basisty N, Song S, Rose J, Lopez-Ramirez A, Naphade S, Loureiro A, Battistoni E, Milani M, Wehrfritz C, Holtz A, Hetz C, Mooney SD, Schilling B, Ellerby LM. Mol Cell Proteomics.2023 Mar 21:100534. doi: 10.1016/j.mcpro.2023.100534.

MARCH 2023

• Forno, G., Parra, M. A., Thumala, D., Villagra, R., Cerda, M., Zitko, P., Ibanez, A., Lillo, P., & Slachevsky, A. (Accepted/In press). The ‘when’ matters: evidence from memory markers in the clinical continuum of Alzheimer’s disease. Neuropsychology. https://pubmed.ncbi.nlm.nih.gov/36813542/
• Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2. Ogonowski N, Santamaria-Garcia H, Baez S, Lopez A, Laserna A, Garcia-Cifuentes E, Ayala-Ramirez P, Zarante I, Suarez-Obando F, Reyes P, Kauffman M, Cochran N, Schulte M, Sirkis DW, Spina S, Yokoyama JS, Miller BL, Kosik KS, Matallana D, Ibáñez A. J Med Genet. 2023 Feb 22. https://pubmed.ncbi.nlm.nih.gov/36813542/
• Event-related potentials associated with attentional networks evidence changes in executive and arousal vigilance. Luna FG, Aguirre MJ, Martín-Arévalo E, Ibáñez A, Lupiáñez J, Barttfeld  Psychophysiology. 2023 Feb 22. https://pubmed.ncbi.nlm.nih.gov/36812133/
• Non-pharmacological prevention of postoperative delirium by occupational therapy teams: A randomized clinical trial. Alvarez EA, Rojas VA, Caipo LI, Galaz MM, Ponce DP, Gutierrez RG, Salech F, Tobar E, Reyes FI, Vergara RC, Egaña JI, Briceño CA, Penna A. Front Med (Lausanne). 2023 Feb 2. https://pubmed.ncbi.nlm.nih.gov/36817762/
• Moral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorders. Baez Sandra, Trujillo-Llano Catalina, de Souza Leonardo Cruz, Lillo Patricia, Forno Gonzalo, Santamaría-García Hernando, Okuma Cecilia, Alegria Patricio, Huepe David, Ibáñez AgustínDecety Jeans, Slachevsky Andrea. Journal of Alzheimer’s Disease, vol. Pre-press, no. Pre-press, pp. 1-17, 2023. https://pubmed.ncbi.nlm.nih.gov/36710684/
• The limitations and challenges in the assessment of executive dysfunction associated with real-world functioning: The opportunity of serious games. David Martínez-Pernía, Loreto Olavarría, Baltasar Fernández-Manjón, Victoria Cabello, Fernando Henríquez, Philippe Robert, Luís Alvarado, Silvia Barría, Andrés Antivilo ,Juan Velasquez, Mauricio Cerda, Gonzalo Farías, Teresa Torralva, Agustín Ibáñez, Mario A. Parra, Sam Gilbert & Andrea Slachevsky.Taylor & Francis online: 24 Feb 2023. https://pubmed.ncbi.nlm.nih.gov/36827177/

FEBRUARY 2023

• Classification of Alzheimer’s disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study. Maito MA, Santamaría-García H, Moguilner S, Possin KL, Godoy ME, Avila-Funes JA, Behrens MI, Brusco IL, Bruno MA, Cardona JF, Custodio N, García AM, Javandel S, Lopera F, Matallana DL, Miller B, de Oliveira MO, Pina-Escudero SD, Slachevsky A, Ortiz ALS, Takada LT, Tagliazuchi E, Valcour V, Yokoyama JS, Ibañez A.Lancet Reg Health Am. 2023 Jan 17. https://pubmed.ncbi.nlm.nih.gov/36583137/
• Overactivation of posterior insular, postcentral, and temporal regions during preserved experience of envy in autism. Fittipaldi S, Armony JL, Migeot J, Cadaveira M, Ibáñez A, Baez S. Eur J Neurosci. 2023 Jan 11. https://pubmed.ncbi.nlm.nih.gov/36628571/
• Comprehensive Evaluation of the Bioactive Composition and Neuroprotective and Antimicrobial Properties of Vacuum-Dried Broccoli (Brassica oleracea var. italica) Powder and Its Antioxidants. Vega-Galvez A, Uribe E, Pasten A, Camus J, Gomez-Perez LS, Mejias N,Vidal RL, Grunenwald F, Aguilera LE, Valenzuela-Barra G. Molecules. 2023 Jan 12. https://pubmed.ncbi.nlm.nih.gov/36677826/

JANUARY 2023

• Neurocognitive patterns across genetic levels in behavioral variant frontotemporal dementia: a multiple single cases study. Hernando Santamaría-García, Natalia Ogonowsky, Sandra Baez, Nicole Palacio, Pablo Reyes, Michael Schulte, Andrea López, Diana Matallana,Agustín Ibanez BMC Neurol. 22(1):454; 2022 Dec 6.  https://doi.org/10.1186/s12883-022-02954-1