PUBLICACIONES 2018

Los estudios desarrollados en nuestro Centro están enfocados en comprender los principios básicos del envejecimiento desde moléculas a sistemas. También buscamos descifrar si la población chilena alberga la mayoría de las propiedades genéticas, moleculares y celulares que se han descrito en cohortes de todo el mundo, o si tiene características únicas.

63 PUBLICACIONES

  • TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons.,Sandoval R, Lazcano P, Ferrari F, Pinto-Pardo N, González-Billault C, Utreras E.,Front Physiol. 2018 Feb 6;9:65,doi: 10.3389/fphys.2018.00065
  • Crosstalk between Rac1-mediated actin regulation and ROS production.,Acevedo A, González-Billault C.,Free Radic Biol Med. 2018 Feb 20;116:101-113.,doi: 10.1016/j.freeradbiomed.2018.01.008.
  • Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging.,Müller M, Ahumada-Castro U, Sanhueza M, Gonzalez-Billault C, Court FA, Cárdenas C.,Front Neurosci. 2018 Jul 13;12:470.,doi: 10.3389/fnins.2018.00470.
  • Editorial: From Ecology to Brain Development: Bridging Separate Evolutionary Paradigms.,Aboitiz F, Concha ML, González-Billault C, Mpodozis J.,Front Neurosci. 2018 Jun 29;12:447,doi: 10.3389/fnins.2018.00447.
  • From birth to death: A role for reactive oxygen species in neuronal development.,Wilson C, Muñoz-Palma E, González-Billault C.,Semin Cell Dev Biol. 2018 Aug;80:43-49, doi: 10.1016/j.semcdb.2017.09.012.
  • IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A.,Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C.,Nat Cell Biol. 2018 Oct;20(10):1228,doi: 10.1038/s41556-018-0186-0.
  • ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship.,Cabral-Miranda F, Hetz C.,Curr Top Microbiol Immunol. 2018;414:131-157.,doi: 10.1007/82_2017_52
  • Unraveling the role of motoneuron autophagy in ALS.,Valenzuela V, Nassif M, Hetz C.,Autophagy. 2018;14(4):733-737, doi: 10.1080/15548627.2018.1432327.
  • The Unfolded Protein Response and Cell Fate Control.,Hetz C, Papa FR.,Mol Cell. 2018 Jan 18;69(2):169-181,doi: 10.1016/j.molcel.2017.06.017
  • Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α.,Sepulveda D, Rojas-Rivera D, Rodríguez DA, Groenendyk J, Köhler A, Lebeaupin C, Ito S, Urra H, Carreras-Sureda A, Hazari Y, Vasseur-Cognet M, Ali MMU, Chevet E, Campos G, Godoy P, Vaisar T, Bailly-Maitre B, Nagata K, Michalak M, Sierralta J, Hetz C.,Mol Cell. 2018 Jan 18;69(2):238-252.e7,doi: 10.1016/j.molcel.2017.12.028.
  • (off)Targeting UPR signaling: the race toward intervening ER proteostasis.,Pérez-Arancibia R, Rivas A, Hetz C.,Expert Opin Ther Targets. 2018 Feb;22(2):97-100,doi: 10.1080/14728222.2018.1420169
  • A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer’s disease.,Gerakis Y, Hetz C.,Neurobiol Aging. 2018 Mar;63:162-164.,doi: 10.1016/j.neurobiolaging.2017.09.012
  • Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer’s disease.,Gerakis Y, Hetz C.,FEBS J. 2018 Mar;285(6):995-1011,doi: 10.1111/febs.14332.
  • Dual IRE1 RNase functions dictate glioblastoma development.,Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E.,EMBO Mol Med. 2018 Mar;10(3). pii: e7929, doi: 10.15252/emmm.201707929
  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.,Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D’Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.,Cell Death Differ. 2018 Mar;25(3):486-541.,doi: 10.1038/s41418-017-0012-4.
  • Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses.,Carreras-Sureda A, Pihán P, Hetz C.,Cell Calcium. 2018 Mar;70:24-31.,doi: 10.1016/j.ceca.2017.08.004.
  • Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson’s disease.,Mercado G, Castillo V, Soto P, López N, Axten JM, Sardi SP, Hoozemans JJM, Hetz C.,Neurobiol Dis. 2018 Apr;112:136-148,doi: 10.1016/j.nbd.2018.01.004
  • Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis.,Matamala JM, Arias-Carrasco R, Sanchez C, Uhrig M, Bargsted L, Matus S, Maracaja-Coutinho V, Abarzua S, van Zundert B, Verdugo R, Manque P, Hetz C.,Neurobiol Aging. 2018 Apr;64:123-138,doi: 10.1016/j.neurobiolaging.2017.12.020
  • ER stress sensing mechanism: Putting off the brake on UPR transducers.,Rojas-Rivera D, Rodriguez DA, Sepulveda D, Hetz C.,Oncotarget. 2018 Apr 13;9(28):19461-19462,doi: 10.18632/oncotarget.25114
  • Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases.,González-Quiroz M, Urra H, Limia CM, Hetz C.,Semin Cancer Biol. 2018 Jun;50:42-52.,doi: 10.1016/j.semcancer.2018.01.011.
  • Gene Therapy Strategies to Restore ER Proteostasis in Disease.,Valenzuela V, Jackson KL, Sardi SP, Hetz C.,Mol Ther. 2018 Jun 6;26(6):1404-1413. ,doi: 10.1016/j.ymthe.2018.04.004
  • Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis.,Medinas DB, Rozas P, Martínez Traub F, Woehlbier U, Brown RH, Bosco DA, Hetz C.,Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8209-8214,doi: 10.1073/pnas.1801109115.
  • ER Proteostasis Control of Neuronal Physiology and Synaptic Function.,Martínez G, Khatiwada S, Costa-Mattioli M, Hetz C.,Trends Neurosci. 2018 Sep;41(9):610-624.,doi: 10.1016/j.tins.2018.05.009.
  • A new model to study cell-to-cell transfer of αSynuclein in vivo.,Mercado G, López N, Martínez A, Sardi SP, Hetz C.,Biochem Biophys Res Commun. 2018 Sep 10;503(3):1385-1393,doi: 10.1016/j.bbrc.2018.07.053
  • Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease.,Lebeaupin C, Vallée D, Hazari Y, Hetz C, Chevet E, Bailly-Maitre B.,J Hepatol. 2018 Oct;69(4):927-947.,doi: 10.1016/j.jhep.2018.06.008.
  • In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia.,López-Leal R, Diaz P, Court FA.,Methods Mol Biol. 2018;1739:255-267,doi: 10.1007/978-1-4939-7649-2_1
  • “Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs.,De Gregorio C, Díaz P, López-Leal R, Manque P, Court FA.,Methods Mol Biol. 2018;1739:299-315.,doi: 10.1007/978-1-4939-7649-2_19.
  • Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis.,Catenaccio A, Court FA.,Methods Mol Biol. 2018;1739:329-337.,doi: 10.1007/978-1-4939-7649-2_21
  • A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies.,Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, Rush T, Vizzuso D, Court FA, Bachi A, Wrabetz L, Feltri ML.,J Neurochem. 2018 May;145(3):245-257,doi: 10.1111/jnc.14295.
  • The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model.,Gonzalez D, Rebolledo DL, Correa LM, Court FA, Cerpa W, Lipson KE, van Zundert B, Brandan E.,Hum Mol Genet. 2018 Aug 15;27(16):2913-2926,doi: 10.1093/hmg/ddy204.
  • Axonal degeneration induced by glutamate-excitotoxicity is mediated by necroptosis.,Hernández DE, Salvadores NA, Moya-Alvarado G, Catalán RJ, Bronfman FC, Court FA.,J Cell Sci. 2018 Oct 17. pii: jcs.214684,doi: 10.1242/jcs.214684.
  • Editorial: Inter-Organelle Calcium Communication in Cancer.,Cardenas C, Pinton P, Bultynck G.,Front Oncol. 2018 Feb 6;8:14,doi: 10.3389/fonc.2018.00014.
  • Targeting hepatic glutaminase activity to ameliorate hyperglycemia.,Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ.,Nat Med. 2018 Sep;24(9):1482,doi: 10.1038/s41591-018-0047-1.
  • FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.,Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, Ramírez-Rodríguez O, Pessoa-Mahana H, Pavani M, Ferreira J, Cárdenas C, Araya-Maturana R.,Sci Rep. 2018 Sep 4;8(1):13190.,doi: 10.1038/s41598-018-31367-9.
  • MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells.,Ahumada-Castro U, Silva-Pavez E, Lovy A, Pardo E, Molgo J, Cárdenas C.,Autophagy. 2018 Oct 23:1-4, doi: 10.1080/15548627.2018.153776
  • Expression of RPRM/rprm in the Olfactory System of Embryonic Zebrafish (Danio rerio).,Stanic K, Quiroz A, Lemus CG, Wichmann IA, Corvalán AH, Owen GI, Opazo JC, Concha ML, Amigo JD.,Front Neuroanat. 2018 Mar 27;12:23.,doi: 10.3389/fnana.2018.00023
  • Neuroanatomical Comparison of the “Word” and “Picture” Versions of the Free and Cued Selective Reminding Test in Alzheimer’s Disease.,Slachevsky A, Barraza P, Hornberger M, Muñoz-Neira C, Flanagan E, Henríquez F, Bravo E, Farías M, Delgado C.,J Alzheimers Dis. 2018;61(2):589-600.,doi: 10.3233/JAD-160973.
  • Structural Anatomical Investigation of Long-Term Memory Deficit in Behavioral Frontotemporal Dementia.,Bertoux M, Flanagan EC, Hobbs M, Ruiz-Tagle A, Delgado C, Miranda M, Ibáñez A, Slachevsky A, Hornberger M.,J Alzheimers Dis. 2018;62(4):1887-1900.,doi: 10.3233/JAD-170771.
  • Dementia in Latin America: Assessing the present and envisioning the future.,Parra MA, Baez S, Allegri R, Nitrini R, Lopera F, Slachevsky A, Custodio N, Lira D, Piguet O, Kumfor F, Huepe D, Cogram P, Bak T, Manes F, Ibanez A.,Neurology. 2018 Jan 30;90(5):222-231,doi: 10.1212/WNL.0000000000004897.
  • Relationship between Social Cognition and traditional cognitive impairment in Progressive Multiple Sclerosis and possible implicated neuroanatomical regions.,Ciampi E, Uribe-San-Martin R, Vásquez M, Ruiz-Tagle A, Labbe T, Cruz JP, Lillo P, Slachevsky A, Reyes D, Reyes A, Cárcamo-Rodríguez C.,Mult Scler Relat Disord. 2018 Feb;20:122-128.,doi: 10.1016/j.msard.2018.01.013.
  • From Snapshots to Movies: The Association Between Retirement Sequences and Aging Trajectories in Limitations to Perform Activities of Daily Living.,Azar A, Staudinger UM, Slachevsky A, Madero-Cabib I, Calvo E.,J Aging Health. 2018 Jun 1:898264318782096,doi: 10.1177/0898264318782096.
  • Corticostriatal signatures of schadenfreude: evidence from Huntington’s disease.,Baez S, Pino M, Berrío M, Santamaría-García H, Sedeño L, García AM, Fittipaldi S, Ibáñez A.,J Neurol Neurosurg Psychiatry. 2018 Jan;89(1):112-116. ,doi: 10.1136/jnnp-2017-316055.
  • Social neuroscience: undoing the schism between neurology and psychiatry.,Ibáñez A, García AM, Esteves S, Yoris A, Muñoz E, Reynaldo L, Pietto ML, Adolfi F, Manes F.,Soc Neurosci. 2018 Feb;13(1):1-39,doi: 10.1080/17470919.2016.1245214.
  • Posterior cortical atrophy: a single case cognitive and radiological follow-up.,Esteves S, Ramirez Romero DA, Torralva T, Martínez Cuitiño M, Herndon S, Couto B, Ibañez A, Manes F, Roca M.,Neurocase. 2018 Feb;24(1):16-30.,doi: 10.1080/13554794.2017.1421667.
  • Early bilateral and massive compromise of the frontal lobes.,Ibáñez A, Zimerman M, Sedeño L, Lori N, Rapacioli M, Cardona JF, Suarez DMA, Herrera E, García AM, Manes F.,Neuroimage Clin. 2018 Feb 27;18:543-552.,doi: 10.1016/j.nicl.2018.02.026.
  • Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE): A Translational, Integrated, and Transdisciplinary Approach.,Paquet M, Cerasuolo JO, Thorburn V, Fridman S, Alsubaie R, Lopes RD, Cipriano LE, Salamone P, Melling CWJ, Khan AR, Sedeño L, Fang J, Drangova M, Montero-Odasso M, Mandzia J, Khaw AV, Racosta JM, Paturel J, Samoilov L, Stirling D, Balint B, Jaremek V, Koschinsky ML, Boffa MB, Summers K, Ibañez A, Mrkobrada M, Saposnik G, Kimpinski K, Whitehead SN, Sposato LA.,J Stroke Cerebrovasc Dis. 2018 Mar;27(3):606-619. ,doi: 10.1016/j.jstrokecerebrovasdis.2017.09.038.
  • Parkinson’s disease compromises the appraisal of action meanings evoked by naturalistic texts.,García AM, Bocanegra Y, Herrera E, Moreno L, Carmona J, Baena A, Lopera F, Pineda D, Melloni M, Legaz A, Muñoz E, Sedeño L, Baez S, Ibáñez A.,Cortex. 2018 Mar;100:111-126.,doi: 10.1016/j.cortex.2017.07.003.
  • When embodiment breaks down: Language deficits as novel avenues into movement disorders.,García AM, Ibáñez A.,Cortex. 2018 Mar;100:1-7.,doi: 10.1016/j.cortex.2017.12.022.
  • Intracranial high-γ connectivity distinguishes wakefulness from sleep.,Mikulan E, Hesse E, Sedeño L, Bekinschtein T, Sigman M, García MDC, Silva W, Ciraolo C, García AM, Ibáñez A.,Neuroimage. 2018 Apr 1;169:265-277,doi: 10.1016/j.neuroimage.2017.12.015.
  • Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions.,Yoris A, Abrevaya S, Esteves S, Salamone P, Lori N, Martorell M, Legaz A, Alifano F, Petroni A, Sánchez R, Sedeño L, García AM, Ibáñez A.,Hum Brain Mapp. 2018 Apr;39(4):1563-1581.,doi: 10.1002/hbm.23933.
  • Beyond the face: how context modulates emotion processing in frontotemporal dementia subtypes.,Kumfor F, Ibañez A, Hutchings R, Hazelton JL, Hodges JR, Piguet O.,Brain. 2018 Apr 1;141(4):1172-1185. ,doi: 10.1093/brain/awy002.
  • Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America.,Ibáñez A, Sedeño L, García AM, Deacon RMJ, Cogram P.,Front Aging Neurosci. 2018 Apr 6;10:95,doi: 10.3389/fnagi.2018.00095.
  • A core avenue for transcultural research on dementia: on the cross-linguistic generalization of language-related effects in Alzheimer’s disease and Parkinson’s disease.,Calvo N, Ibáñez A, Muñoz E, García AM.,Int J Geriatr Psychiatry. 2018 Jun;33(6):814-823. ,doi: 10.1002/gps.4712.
  • Action Semantics at the Bottom of the Brain: Insights From Dysplastic Cerebellar Gangliocytoma.,Cervetto S, Abrevaya S, Martorell Caro M, Kozono G, Muñoz E, Ferrari J, Sedeño L, Ibáñez A, García AM.,Front Psychol. 2018 Jul 12;9:1194. ,doi: 10.3389/fpsyg.2018.01194
  • Weighted Symbolic Dependence Metric (wSDM) for fMRI resting-state connectivity: A multicentric validation for frontotemporal dementia.,Moguilner S, García AM, Mikulan E, Hesse E, García-Cordero I, Melloni M, Cervetto S, Serrano C, Herrera E, Reyes P, Matallana D, Manes F, Ibáñez A, Sedeño L.,Sci Rep. 2018 Jul 25;8(1):11181.,doi: 10.1038/s41598-018-29538-9
  • The long-lived Octodon degus as a rodent drug discovery model for Alzheimer’s and other age-related diseases.,Hurley MJ, Deacon RMJ, Beyer K, Ioannou E, Ibáñez A, Teeling JL, Cogram P.,Pharmacol Ther. 2018 Aug;188:36-44. ,doi: 10.1016/j.pharmthera.2018.03.001.
  • Altered neural signatures of interoception in multiple sclerosis.,Salamone PC, Esteves S, Sinay VJ, García-Cordero I, Abrevaya S, Couto B, Adolfi F, Martorell M, Petroni A, Yoris A, Torquati K, Alifano F, Legaz A, Cassará FP, Bruno D, Kemp AH, Herrera E, García AM, Ibáñez A, Sedeño L.,Hum Brain Mapp. 2018 Aug 4.,doi: 10.1002/hbm.24319.
  • Action-semantic and syntactic deficits in subjects at risk for Huntington’s disease.,García AM, Bocanegra Y, Herrera E, Pino M, Muñoz E, Sedeño L, Ibáñez A.,J Neuropsychol. 2018 Sep;12(3):389-408,doi: 10.1111/jnp.12120.
  • Commentary: Cerebellar atrophy and its contribution to cognition in frontotemporal dementias.,Ibáñez A, García AM.,Front Aging Neurosci. 2018 Oct 1;10:300.,doi: 10.3389/fnagi.2018.00300.
  • Brain oscillations, inhibition and social inappropriateness in frontotemporal degeneration.,Ibáñez A.,Brain. 2018 Oct 1;141(10):e73. ,doi: 10.1093/brain/awy233.