PUBLICACIONES 2019

Los estudios desarrollados en nuestro Centro están enfocados en comprender los principios básicos del envejecimiento desde moléculas a sistemas. También buscamos descifrar si la población chilena alberga la mayoría de las propiedades genéticas, moleculares y celulares que se han descrito en cohortes de todo el mundo, o si tiene características únicas.

54 PUBLICACIONES

  • Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis, Beltran, S., Nassif, M., Vicencio, E., Arcos, J., Labrador, L., Cortes, B., Cortez, C., Bergmann, C., Espinoza, S., Hernandez, M., Matamala, J., Bargsted, L., Matus, S., Rojas-Rivera, D., Bertrand, M., Medinas, D., Hetz, C., Manque, P. and Woehlbier, U., Molecular Neurodegeneration. 2019, 14(1)
  • Predictors of unmet needs in Chilean older people with dementia: a cross-sectional study, Tapia Muñoz T, Slachevsky A, León-Campos MO, Madrid M, Caqueo-Urízar A, Rohde GC, Miranda-Castillo C., BMC Geriatr. 2019 Apr 15;19(1):106
  • Nutrient Sensing and Redox Balance: GCN2 as a New Integrator in Aging, Falcón, P., Escandón, M., Brito, Á. and Matus, S., Oxidative Medicine and Cellular Longevity, 2019, pp.1-9
  • The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish, Stanic, K., Reig, G., Wichmann, I., Opazo, J., Owen, G., Corvalán, A., Concha, M. and Amigo, J., Scientific Reports, 9(1)
  • Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics, Carreras-Sureda, A., Jaña, F., Urra, H., Durand, S., Mortenson, D., Sagredo, A., Bustos, G., Hazari, Y., Ramos-Fernández, E., Sassano, M., Pihán, P., van Vliet, A., González-Quiroz, M., Torres, A., Tapia-Rojas, C., Kerkhofs, M., Vicente, R., Kaufman, R., Inestrosa, N., Gonzalez-Billault, C., Wiseman, R., Agostinis, P., Bultynck, G., Court, F., Kroemer, G., Cárdenas, J. and Hetz, C., Nature Cell Biology. 2019, 21(6), pp.755-767
  • Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion, Limia, C., Sauzay, C., Urra, H., Hetz, C., Chevet, E. and Avril, T., Cancers. 2019, 11(5), p.631
  • Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models, Bodaleo F, Tapia-Monsalves C, Cea-Del Rio C, Gonzalez-Billault C, Nunez-Parra A., Front Mol Neurosci. 2019 May 28;12:135
  • Axonal Degeneration Is Mediated by Necroptosis Activation, rrázola MS, Saquel C, Catalán RJ, Barrientos SA, Hernandez DE, Martínez NW, Catenaccio A, Court FA., Neurosci. 2019 May 15;39(20):3832-3844
  • Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of daily living, Slachevsky A, Forno G, Barraza P, Mioshi E, Delgado C, Lillo P, Henriquez F, Bravo E, Farias M, Muñoz-Neira C, Ibañez A, Parra MA, Hornberger M., Neurol. 2019 Jun;266(6):1310-1322
  • β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation, Pinto, C., Medinas, D., Fuentes-Villalobos, F., Maripillán, J., Castro, A., Martínez, A., Osses, N., Hetz, C. and Henríquez, J., Neurobiology of Disease. 2019, 130, p.104497
  • Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice, Kline RA, Dissanayake KN, Hurtado ML, Martínez NW, Ahl A, Mole AJ, Lamont DJ, Court FA, Ribchester RR, Wishart TM, Murray LM., Neurobiol Dis. 2019 Jun;130:104496
  • Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders, Espinosa-Parrilla Y, Gonzalez-Billault C, Fuentes E, Palomo I, Alarcón M., Front Aging Neurosci. 2019 Jul 2;11:151
  • Cell migration driven by substrate deformation gradients, Marquez, S., Reig Cardarella, G., Concha, M. and Soto, R., Physical Biology. 2019
  • Pharmacological targeting of the unfolded protein response for disease intervention, Hetz, C., Axten, J. and Patterson, J., Nature Chemical Biology. 2019, 15(8), pp.764-775
  • Microtubule-Associated Proteins: Structuring the Cytoskeleton, Bodakuntla S, Jijumon AS, Villablanca C, Gonzalez-Billault C, Janke C., Trends Cell Biol. 2019 Aug 12. pii: S0962-8924(19)30120-5
  • Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology, Arrazola MS, Court FA., Neural Regen Res. 2019 Aug;14(8):1385-1386
  • Recommendations for the Nonpharmacological Treatment of Apathy in Brain Disorders, Manera V, Abrahams S, Agüera-Ortiz L, Bremond F, David R, Fairchild K, Gros A, Hanon C, Husain M, König A, Lockwood PL, Pino M, Radakovic R, Robert G, Slachevsky A, Stella F, Tribouillard A, Trimarchi PD, Verhey F, Yesavage J, Zeghari R, Robert P, Am J Geriatr Psychiatry. 2019 Aug 9. pii: S1064-7481(19)30459-2
  • Small Molecules to Improve ER Proteostasis in Disease, Gonzalez-Teuber, V., Albert-Gasco, H., Auyeung, V., Papa, F., Mallucci, G. and Hetz, C., Trends in Pharmacological Sciences. 2019, 40(9), pp.684-695
  • The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability, Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP., Acta Neuropathol Commun. 2019 Sep 12;7(1):147
  • Microtubule-Associated Proteins: Structuring the Cytoskeleton, Bodakuntla S, Jijumon AS, Villablanca C, Gonzalez-Billault C, Janke C., Trends Cell Biol. 2019 Oct;29(10):804-819.
  • The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease, Oñate M, Catenaccio A, Salvadores N, Saquel C, Martinez A, Moreno-Gonzalez I, Gamez N, Soto P, Soto C, Hetz C, Court FA., Cell Death Differ. 2019 Oct 7.
  • Saved by the Matrix: UPR Independent Survival under ER Stress, Koopman M, Hetz C, Nollen EAA., Cell. 2019 Nov 27;179(6):1246-1248.
  • Dopamine Receptor D3 Signalling in Astrocytes Promotes Neuroinflammation, Andro Montoya, Daniela Elgueta, Javier Campos, Ornella Chovar, Paulina Falcón, Soledad Matus, Iván Alfaro, María Rosa Bono & Rodrigo Pacheco, J Neuroinflammation. 2019 Dec 6;16(1):258.
  • Complex I and II Regulate Mitochondrial Ca2+ Homeostasis Independent of the Mitochondrial Membrane Potential, Jaňa, F., Bustos, G., Cruz, P., Lovy, A., Dong, Z., Madesh, M., and Cardenas, C., Mitochondrion.13;49:73-82. 2019
  • Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep, Gonzalez-Candia A, Veliz M, Carrasco-Pozo C, Castillo RL, Cárdenas JC, Ebensperger G, Reyes RV, Llanos AJ, Herrera EA., Redox Biology. 22: 101128. 2019.
  • MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells, Ahumada-Castro, U., Silva-Pavez, E., Pardo, E., Lovy, A., and Cárdenas, C., Autophagy. 15(2):358-361, 2019
  • The UFMylation System in Proteostasis and Beyond, Yannis Gerakis, Michaela Quintero, Honglin Li, Claudio Hetz, Trends Cell Biol. 2019 Dec;29(12):974-986
  • The p75 NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability, Viviana Pérez, Francisca Bermedo-Garcia, Diego Zelada, Felipe A Court, Miguel Ángel Pérez, Marco Fuenzalida, Johanna Ábrigo, Claudio Cabello-Verrugio, Guillermo Moya-Alvarado, Juan Carlos Tapia, Vicente Valenzuela, Claudio Hetz, Francisca C Bronfman, Juan Pablo Henríquez, Acta Neuropathol Commun. 2019 Sep 12;7(1):147.
  • Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics, Amado Carreras-Sureda, Fabián Jaña, Hery Urra, Sylvere Durand, David E Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, Maria L Sassano, Philippe Pihán, Alexander R van Vliet Matías González-Quiroz, Angie K Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, Rubén Vicente, Randal J Kaufman, Nibaldo C Inestrosa, Christian Gonzalez-Billault, R Luke Wiseman, Patrizia Agostinis, Geert Bultynck, Felipe A Court, Guido Kroemer, J César Cárdenas, Claudio Hetz, Nat Cell Biol. 2019 Jun;21(6):755-767.
  • Targeting of the unfolded protein response (UPR) as therapy for Parkinson’s disease, Alexis Martinez, Nelida Lopez, Constanza Gonzalez, Claudio Hetz, Biol Cell. 2019 Jun;111(6):161-168
  • Brain organoids: a next step for humanized Alzheimer’s disease models? Yannis Gerakis, Claudio Hetz, Mol Psychiatry. 2019 Apr;24(4):474-478.
  • ER stress links aging to sporadic ALS, Danilo B Medinas, Felipe Cabral-Miranda, Claudio Hetz, Aging (Albany NY). 2019 Jan 5;11(1):5-6
  • From Snapshots to Movies: The Association Between Retirement Sequences and Aging Trajectories in Limitations to Perform Activities of Daily Living, Ariel Azar, Ursula M Staudinger, Andrea Slachevsky, Ignacio Madero-Cabib, Esteban Calvo, J Aging Health. 2019 Feb;31(2):293-321
  • Fronto-Subcortical Circuits for Cognition and Motivation: Dissociated Recovery in a Case of Loss of Psychic Self-Activation, Rodrigo Riveros, Serge Bakchine, Bernard Pillon, Fabrice Poupon, Marcelo Miranda, Andrea Slachevsky, Front Psychol. 2019 Jan 23;9:2781.
  • Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach, M Belen Bachli, Lucas Sedeño, Jeremi K Ochab, Olivier Piguet, Fiona Kumfor, Pablo Reyes, Teresa Torralva, María Roca, Juan Felipe Cardona, Cecilia Gonzalez Campo, Eduar Herrera, Andrea Slachevsky, Diana Matallana, Facundo Manes, Adolfo M García, Agustín Ibáñez, Dante R Chialvo, Neuroimage. 2020 Mar;208:116456.
  • Neuropsychiatric Symptoms in Alzheimer’s Disease Are the Main Determinants of Functional Impairment in Advanced Everyday Activities, Carolina Delgado, Rodrigo C Vergara, Melissa Martínez, Gada Musa, Fernando Henríquez, Andrea Slachevsky, J Alzheimers Dis. 2019;67(1):381-392.
  • Insular networks and intercognition in the wild, Agustín Ibáñez, Cortex. 2019 Jun;115:341-344
  • Assessment of Conjunctive Binding in Aging: A Promising Approach for Alzheimer’s Disease Detection, Juan F Martínez, Catalina Trujillo, Analía Arévalo, Agustín Ibáñez, Juan F Cardona, J Alzheimers Dis. 2019;69(1):71-81.
  • Explicit and implicit monitoring in neurodegeneration and stroke, Indira Garcia-Cordero, Lucas Sedeño, Andrés Babino, Martín Dottori, Margherita Melloni, Miguel Martorell Caro, Mariano Sigman, Eduar Herrera, Facundo Manes, Adolfo M García, Agustín Ibáñez, Sci Rep. 2019 Oct 1;9(1):14032.
  • Negation markers inhibit motor routines during typing of manual action verbs, Enrique García-Marco, Yurena Morera, David Beltrán, Manuel de Vega, Eduar Herrera, Lucas Sedeño, Agustín Ibáñez, Adolfo M García, Cognition. 2019 Jan;182:286-293
  • Network analysis through the use of joint-distribution entropy on EEG recordings of MCI patients during a visual short-term memory binding task, Alexandra Josefsson, Agustín Ibáñez, Mario Parra, Javier Escudero, Healthc Technol Lett. 2019 Mar 29;6(2):27-31
  • Rethinking the Neural Basis of Prosody and Non-literal Language: Spared Pragmatics and Cognitive Compensation in a Bilingual With Extensive Right-Hemisphere Damage, Noelia Calvo, Sofía Abrevaya, Macarena Martínez Cuitiño, Brenda Steeb, Dolores Zamora, Lucas Sedeño, Agustín Ibáñez Adolfo M García, Front Psychol. 2019 Mar 19;10:570
  • Out of Context, Beyond the Face: Neuroanatomical Pathways of Emotional Face-Body Language Integration in Adolescent Offenders, Hernando Santamaría-García, Agustin Ibáñez, Synella Montaño, Adolfo M García, Michel Patiño-Saenz, Claudia Idarraga, Mariana Pino, Sandra Baez, Front Behav Neurosci. 2019 Feb 26;13:34
  • Consistent Gradient of Performance and Decoding of Stimulus Type and Valence From Local and Network Activity, Eugenia Hesse, Ezequiel Mikulan, Jacobo D Sitt, Maria Del Carmen Garcia, Walter Silva, Carlos Ciraolo, Esteban Vaucheret, Federico Raimondo, Fabricio Baglivo, Federico Adolfi, Eduar Herrera, Tristan A Bekinschtein, Agustin Petroni, Sergio Lew, Lucas Sedeno, Adolfo M Garcia, Agustin Ibanez, IEEE Trans Neural Syst Rehabil Eng. 2019 Apr;27(4):619-629.
  • How meaning unfolds in neural time: Embodied reactivations can precede multimodal semantic effects during language processing, Adolfo M García, Sebastian Moguilner, Kathya Torquati, Enrique García-Marco, Eduar Herrera, Edinson Muñoz, Eduardo M Castillo, Tara Kleineschay, Lucas Sedeño, Agustín Ibáñez, Neuroimage. 2019 Aug 15;197:439-449
  • Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington’s disease, Maria Del C Valdés Hernández, Janna Abu-Hussain, Xinyi Qiu, Josef Priller, Mario Parra Rodríguez, Mariana Pino, Sandra Báez, Agustín Ibáñez, Brain Behav. 2019 Aug;9(8):e01343.
  • Reading Shakespearean tropes in a foreign tongue: Age of L2 acquisition modulates neural responses to functional shifts, Martina G Vilas, Micaela Santilli, Ezequiel Mikulan, Federico Adolfi, Miguel Martorell Caro, Facundo Manes, Eduar Herrera, Lucas Sedeño, Agustín Ibáñez, Adolfo M García, Neuropsychologia. 2019 Feb 18;124:79-86
  • Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine, Alethia de la Fuente, Lucas Sedeño, Sofia Schurmann Vignaga, Camila Ellmann, Silvina Sonzogni, Laura Belluscio, Indira García-Cordero, Eugenia Castagnaro, Magdalena Boano, Marcelo Cetkovich, Teresa Torralva, Eduardo T Cánepa, Enzo Tagliazucchi, Adolfo M Garcia, Agustín Ibañez, Neuropsychopharmacology. 2019 Jul;44(8):1425-1434.
  • Too late to be grounded? Motor resonance for action words acquired after middle childhood, Boris Kogan, Edinson Muñoz, Agustín Ibáñez, Adolfo M García, Brain Cogn. 2020 Feb;138:105509
  • Robust automated computational approach for classifying frontotemporal neurodegeneration: Multimodal/multicenter neuroimaging, Patricio Andres Donnelly-Kehoe, Guido Orlando Pascariello, Adolfo M García, John R Hodges, Bruce Miller, Howie Rosen, Facundo Manes, Ramon Landin-Romero, Diana Matallana, Cecilia Serrano, Eduar Herrera, Pablo Reyes, Hernando Santamaria-Garcia, Fiona Kumfor, Olivier Piguet, Agustin Ibanez, Lucas Sedeño, Alzheimers Dement (Amst). 2019 Aug 28;11:588-598.
  • Fatigue in multiple sclerosis is associated with multimodal interoceptive abnormalities, Cecilia Gonzalez Campo, Paula C Salamone, Nicolás Rodríguez-Arriagada, Fabian Richter, Eduar Herrera, Diana Bruno, Fátima Pagani Cassara, Vladimiro Sinay, Adolfo M García, Agustín Ibáñez, Lucas Sedeño, Mult Scler. 2020 Dec;26(14):1845-1853
  • Disarming Ex-Combatants’ Minds: Toward Situated Reintegration Process in Post-conflict Colombia, Sandra Baez, Hernando Santamaría-García, Agustín Ibáñez, Front Psychol. 2019 Jan 29;10:73
  • The Embodied Penman: Effector-Specific Motor-Language Integration During Handwriting, Olivia Afonso, Paz Suárez-Coalla, Fernando Cuetos, Agustín Ibáñez, Lucas Sedeño , Adolfo M García, Cogn Sci. 2019 Jul;43(7):e12767.
  • More than words: Social cognition across variants of primary progressive aphasia, Sol Fittipaldi, Agustín Ibanez, Sandra Baez, Facundo Manes, Lucas Sedeno, Adolfo M Garcia, Neurosci Biobehav Rev. 2019 May;100:263-284.