PUBLICACIONES 2021

Los estudios desarrollados en nuestro Centro están enfocados en comprender los principios básicos del envejecimiento desde moléculas a sistemas. También buscamos descifrar si la población chilena alberga la mayoría de las propiedades genéticas, moleculares y celulares que se han descrito en cohortes de todo el mundo, o si tiene características únicas.

19 PUBLICACIONES

The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All? Victoria Rozés-Salvador, Christian González-Billault, Cecilia Conde. Front Cell Dev Biol. 2020 Dec 10;8:603794. DOI: 10.3389/fcell.2020.603794

Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells. Pablo Cruz, Ulises Ahumada-Castro, Galdo Bustos, Jordi Molgó, Daniela Sauma, Alenka Lovy, César Cárdenas. Int J Mol Sci. 2021 Jan 11;22(2):651. DOI: 10.3390/ijms22020651

Tuba Activates Cdc42 during Neuronal Polarization Downstream of the Small GTPase Rab8a. Pamela J Urrutia, Felipe Bodaleo, Daniel A Bórquez, Yuta Homma, Victoria Rozes-Salvador, Cristopher Villablanca, Cecilia Conde, Mitsunori Fukuda, Christian González-Billault. J Neurosci. 2021 Feb 24;41(8):1636-1649. DOI: 10.1523/JNEUROSCI.0633-20.2020

Dementia in Latin America: Paving the way toward a regional action plan. Mario Alfredo Parra, Sandra Baez, Lucas Sedeño, Cecilia Gonzalez Campo, Hernando Santamaría‐García, Ivan Aprahamian, Paulo HF Bertolucci, Julian Bustin, Maria Aparecida Camargos Bicalho, Carlos Cano‐Gutierrez, Paulo Caramelli, Marcia L. F. Chaves, Patricia Cogram, Bárbara Costa Beber, Felipe A. Court, Leonardo Cruz de Souza, Nilton Custodio, Andres Damian, Myriam de la Cruz, Roberta Diehl Rodriguez, Sonia Maria Dozzi Brucki, Lais Fajersztajn, Gonzalo A. Farías, Fernanda G. De Felice, Raffaele Ferrari, Fabricio Ferreira de Oliveira, Sergio T. Ferreira, Ceres Ferretti, Marcio Luiz Figueredo Balthazar, Norberto Anizio Ferreira Frota, Patricio Fuentes, Adolfo M. García, Patricia J. Garcia, Fábio Henrique de Gobbi Porto, Lissette Duque Peñailillo, Henry Willy Engler, Irene Maier, Ignacio F. Mata, Christian Gonzalez‐Billault, Oscar L. Lopez, Laura Morelli, Ricardo Nitrini, Yakeel T. Quiroz, Alejandra Guerrero Barragan, David Huepe, Fabricio Joao Pio, Claudia Kimie Suemoto, Renata Kochhann, Silvia Kochen, Fiona Kumfor, Serggio Lanata, Bruce Miller, Leticia Lessa Mansur, Mirna Lie Hosogi, Patricia Lillo, Jorge Llibre Guerra, David Lira, Francisco Lopera, Adelina Comas, José Alberto Avila‐Funes, Ana Luisa Sosa, Claudia Ramos, Elisa de Paula França Resende, Heather M. Snyder, Ioannis Tarnanas, Jenifer Yokoyama, Juan Llibre, Juan Felipe Cardona, Kate Possin, Kenneth S. Kosik, Rosa Montesinos, Sebastian Moguilner, Patricia Cristina Lourdes Solis, Renata Eloah de Lucena Ferretti‐Rebustini, Jeronimo Martin Ramirez, Diana Matallana, Lingani Mbakile‐Mahlanza, Alyne Mendonça Marques Ton, Ronnielly Melo Tavares, Eliane C Miotto, Graciela Muniz‐Terrera, Luis Arnoldo Muñoz‐Nevárez, David Orozco, Maira Okada de Oliveira, Olivier Piguet, Maritza Pintado Caipa, Stefanie Danielle Piña Escudero, Lucas Porcello Schilling, André Luiz Rodrigues Palmeira, Mônica Sanches Yassuda, Jose Manuel Santacruz‐Escudero, Rodrigo Bernardo Serafim, Jerusa Smid, Andrea Slachevsky, Cecilia Serrano, Marcio Soto‐Añari, Leonel Tadao Takada, Lea Tenenholz Grinberg, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Dominic Trépel, Agustin Ibanez. Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration. René L Vidal, Denisse Sepulveda, Paulina Troncoso-Escudero, Paula Garcia-Huerta, Constanza Gonzalez, Lars Plate, Carolina Jerez, José Canovas, Claudia A Rivera, Valentina Castillo, Marisol Cisternas, Sirley Leal, Alexis Martinez, Julia Grandjean, Donzelli Sonia, Hilal A Lashuel, Alberto J M Martin, Veronica Latapiat, Soledad Matus, S Pablo Sardi, R Luke Wiseman, Claudio Hetz. Mol Ther. 2021 Feb 3;S1525-0016(21)00067-8. doi: 10.1016/j.ymthe.2021.01.033

Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS. Pablo Rozas, Cristina Pinto, Francisca Martínez Traub, Rodrigo Díaz, Viviana Pérez, Daniela Becerra, Patricia Ojeda, Jorge Ojeda, Madison T Wright, Jessica Mella, Lars Plate, Juan Pablo Henríquez, Claudio Hetz, Danilo B Medinas. Acta Neuropathol Commun. 2021 Feb 4;9(1):21. doi: 10.1186/s40478-020-01116-z.

Therapeutic potential of insulin-like growth factor 2 in Huntington’s disease: controlling proteostasis to alleviate the load of misfolded protein. Paulina Troncoso-Escudero, Claudio Hetz, Rene L Vidal. Neural Regen Res. 2021 Aug;16(8):1564-1565. doi: 10.4103/1673-5374.303020.

DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer’s Disease Patients and a Transgenic Model of the Disease. Esteban Leyton, Diego Matus, Sandra Espinoza, José Matías Benitez, Bastián I Cortes, Wileidy Gomez, Nohela B Arévalo, Paola Murgas, Patricio Manque, Ute Woehlbier, Claudia Duran-Aniotz, Claudio Hetz, María Isabel Behrens, Carol D SanMartín, Melissa Nassif. J Alzheimers Dis. 2021 Feb 19. doi: 10.3233/JAD-201264.

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases. Jun Ren, Yaguang Bi, James R Sowers, Claudio Hetz, Yingmei Zhang. Nat Rev Cardiol. 2021 Feb 22. doi: 10.1038/s41569-021-00511-w.

The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science. Agustin Ibanez, Jennifer S Yokoyama, Katherine L Possin, Diana Matallana, Francisco Lopera, Ricardo Nitrini, Leonel T Takada, Nilton Custodio, Ana Luisa Sosa Ortiz, José Alberto Avila-Funes, Maria Isabel Behrens, Andrea Slachevsky, Richard M Myers, J Nicholas Cochran, Luis Ignacio Brusco, Martin A Bruno, Sonia M D Brucki, Stefanie Danielle Pina-Escudero, Maira Okada de Oliveira, Patricio Donnelly Kehoe, Adolfo M Garcia, Juan Felipe Cardona, Hernando Santamaria-Garcia, Sebastian Moguilner, Claudia Duran-Aniotz, Enzo Tagliazucchi, Marcelo Maito, Erika Mariana Longoria Ibarrola, Maritza Pintado-Caipa, Maria Eugenia Godoy, Vera Bakman, Shireen Javandel, Kenneth S Kosik, Victor Valcour, Bruce L Miller. Front Neurol. 2021 Mar 11;12:631722. doi: 10.3389/fneur.2021.631722.

Adapting the proteostasis capacity to sustain brain healthspan. Claudio Hetz. Cell. 2021 Mar 18;184(6):1545-1560. doi: 10.1016/j.cell.2021.02.007.

Retinal Ganglion Cells Functional Changes in a Mouse Model of Alzheimer’s Disease Are Linked with Neurotransmitter Alterations. Joaquín Araya, Felipe Bello, Gaganashree Shivashankar, David Neira, Claudia Durán-Aniotz, Mónica L Acosta, María José Escobar, Claudio Hetz, Max Chacón, Adrián G Palacios. J Alzheimers Dis. 2021 Mar 13. doi: 10.3233/JAD-201195.

Impact of Social Isolation on People with Dementia and Their Family Caregivers. Lílian Viana Dos Santos Azevedo, Ismael Luis Calandri, Andrea Slachevsky, Héctor Gastón Graviotto, Maria Carolina Santos Vieira, Caíssa Bezerra de Andrade, Adriana Peredo Rossetti, Alana Barroso Generoso, Karoline Carvalho Carmona, Ludmilla Aparecida Cardoso Pinto, Marcos Sorbara, Alejandra Pinto, Tania Guajardo, Loreto Olavarria, Daniela Thumala, Lucía Crivelli, Ludmila Vivas, Ricardo Francisco Allegri, Maira Tonidandel Barbosa, Cecilia M Serrano, Claudia Miranda-Castillo, Paulo Caramelli. J. Alzheimers Dis. 2021 Mar 30. doi: 10.3233/JAD-201580.

In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca 2+ Fluxes. Ulises Ahumada-Castro, Galdo Bustos, Eduardo Silva-Pavez, Andrea Puebla-Huerta, Alenka Lovy, César Cárdenas. Front Cell Dev Biol. 2021 Mar 2;9:629522. doi: 10.3389/fcell.2021.629522

Interoception primes emotional processing: Multimodal evidence from neurodegeneration. Paula C. Salamone, Agustina Legaz, Lucas Sedeño, Sebastián Moguilner, Matías Fraile-Vazquez, Cecilia Gonzalez Campo, Sol Fittipaldi, Adrián Yoris, Magdalena Miranda, Agustina Birba, Agostina Galiani, Sofía Abrevaya, Alejandra Neely, Miguel Martorell Caro, Florencia Alifano, Roque Villagra, Florencia Anunziata, Maira Okada de Oliveira, Ricardo M. Pautassi, Andrea Slachevsky, Cecilia Serrano, Adolfo M. García and Agustín Ibañez. Journal of Neuroscience 7 April 2021, JN-RM-2578-20. DOI: https://doi.org/10.1523/JNEUROSCI.2578-20.2021

Neuron-intrinsic origin of hyperexcitability during early pathogenesis of Alzheimer’s disease: An Editorial Highlight for “Hippocampal hyperactivity in a rat model of Alzheimer’s disease” on https://doi.org/10.1111/jnc.15323. Dasfne Lee-Liu, Christian Gonzalez-Billault. J Neurochem. 2021 Apr 28. DOI: 10.1111/jnc.15248

The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America. Ganesh M Babulal, Valeria L Torres, Daisy Acosta, Cinthya Agüero, Sara Aguilar-Navarro, Rebecca Amariglio, Juliana Aya Ussui, Ana Baena, Yamile Bocanegra 5, Sonia Maria Dozzi Brucki, Julian Bustin, Diego M Cabrera, Nilton Custodio, Monica M Diaz, Lissette Duque Peñailillo, Idalid Franco, Jennifer R Gatchel, Ana Paola Garza-Naveda, Mariana González Lara, Lidia Gutiérrez-Gutiérrez, Edmarie Guzmán-Vélez, Bernard J Hanseeuw, Ivonne Z Jimenez-Velazquez, Tomás León Rodríguez, Jorge Llibre-Guerra, María J Marquine, Jairo Martinez, Luis D Medina, Claudia Miranda-Castillo, Alejandra Morlett Paredes, Diana Munera, Alberto Nuñez-Herrera, Maira Okada de Oliveira, Santiago J Palmer-Cancel, Enmanuelle Pardilla-Delgado, Jaime Perales-Puchalt, Celina Pluim, Liliana Ramirez-Gomez, Dorene M Rentz, Claudia Rivera-Fernández, Monica Rosselli, Cecilia M Serrano, Maria Jose Suing-Ortega, Andrea Slachevsky, Marcio Soto-Añari, Reisa A Sperling, Fernando Torrente, Daniela Thumala, Patrizia Vannini, Clara Vila-Castelar, Tatiana Yañez-Escalante, Yakeel T Quiroz. EClinicalMedicine. 2021 Apr 27;35:100848. doi: 10.1016/j.eclinm.2021.100848.

Building brain capital. Harris A Eyre, Rym Ayadi, William Ellsworth, Gowri Aragam, Erin Smith, Walter D Dawson, Agustin Ibanez, Cara Altimus, Michael Berk, Husseini K Manji, Eric A Storch, Marion Leboyer, Naoko Kawaguchi, Michael Freeman, Patrick Brannelly, Facundo Manes, Sandra B Chapman, Jeffrey Cummings, Carol Graham, Benjamin F Miller, Zoltan Sarnyai, Retsina Meyer, William Hynes. Neuron. 2021 May 5;109(9):1430-1432. doi: 10.1016/j.neuron.2021.04.007.

Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders. Danilo B Medinas, Younis Hazari, Claudio Hetz. Prog Mol Subcell Biol. 2021;59:239-278. doi: 10.1007/978-3-030-67696-4_12.