PUBLICACIONES 2021

Los estudios desarrollados en nuestro Centro están enfocados en comprender los principios básicos del envejecimiento desde moléculas a sistemas. También buscamos descifrar si la población chilena alberga la mayoría de las propiedades genéticas, moleculares y celulares que se han descrito en cohortes de todo el mundo, o si tiene características únicas.

40 PUBLICACIONES

The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All? Victoria Rozés-Salvador, Christian González-Billault, Cecilia Conde. Front Cell Dev Biol. 2020 Dec 10;8:603794. DOI: 10.3389/fcell.2020.603794

Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells. Pablo Cruz, Ulises Ahumada-Castro, Galdo Bustos, Jordi Molgó, Daniela Sauma, Alenka Lovy, César Cárdenas. Int J Mol Sci. 2021 Jan 11;22(2):651. DOI: 10.3390/ijms22020651

Tuba Activates Cdc42 during Neuronal Polarization Downstream of the Small GTPase Rab8a. Pamela J Urrutia, Felipe Bodaleo, Daniel A Bórquez, Yuta Homma, Victoria Rozes-Salvador, Cristopher Villablanca, Cecilia Conde, Mitsunori Fukuda, Christian González-Billault. J Neurosci. 2021 Feb 24;41(8):1636-1649. DOI: 10.1523/JNEUROSCI.0633-20.2020

Dementia in Latin America: Paving the way toward a regional action plan. Mario Alfredo Parra, Sandra Baez, Lucas Sedeño, Cecilia Gonzalez Campo, Hernando Santamaría‐García, Ivan Aprahamian, Paulo HF Bertolucci, Julian Bustin, Maria Aparecida Camargos Bicalho, Carlos Cano‐Gutierrez, Paulo Caramelli, Marcia L. F. Chaves, Patricia Cogram, Bárbara Costa Beber, Felipe A. Court, Leonardo Cruz de Souza, Nilton Custodio, Andres Damian, Myriam de la Cruz, Roberta Diehl Rodriguez, Sonia Maria Dozzi Brucki, Lais Fajersztajn, Gonzalo A. Farías, Fernanda G. De Felice, Raffaele Ferrari, Fabricio Ferreira de Oliveira, Sergio T. Ferreira, Ceres Ferretti, Marcio Luiz Figueredo Balthazar, Norberto Anizio Ferreira Frota, Patricio Fuentes, Adolfo M. García, Patricia J. Garcia, Fábio Henrique de Gobbi Porto, Lissette Duque Peñailillo, Henry Willy Engler, Irene Maier, Ignacio F. Mata, Christian Gonzalez‐Billault, Oscar L. Lopez, Laura Morelli, Ricardo Nitrini, Yakeel T. Quiroz, Alejandra Guerrero Barragan, David Huepe, Fabricio Joao Pio, Claudia Kimie Suemoto, Renata Kochhann, Silvia Kochen, Fiona Kumfor, Serggio Lanata, Bruce Miller, Leticia Lessa Mansur, Mirna Lie Hosogi, Patricia Lillo, Jorge Llibre Guerra, David Lira, Francisco Lopera, Adelina Comas, José Alberto Avila‐Funes, Ana Luisa Sosa, Claudia Ramos, Elisa de Paula França Resende, Heather M. Snyder, Ioannis Tarnanas, Jenifer Yokoyama, Juan Llibre, Juan Felipe Cardona, Kate Possin, Kenneth S. Kosik, Rosa Montesinos, Sebastian Moguilner, Patricia Cristina Lourdes Solis, Renata Eloah de Lucena Ferretti‐Rebustini, Jeronimo Martin Ramirez, Diana Matallana, Lingani Mbakile‐Mahlanza, Alyne Mendonça Marques Ton, Ronnielly Melo Tavares, Eliane C Miotto, Graciela Muniz‐Terrera, Luis Arnoldo Muñoz‐Nevárez, David Orozco, Maira Okada de Oliveira, Olivier Piguet, Maritza Pintado Caipa, Stefanie Danielle Piña Escudero, Lucas Porcello Schilling, André Luiz Rodrigues Palmeira, Mônica Sanches Yassuda, Jose Manuel Santacruz‐Escudero, Rodrigo Bernardo Serafim, Jerusa Smid, Andrea Slachevsky, Cecilia Serrano, Marcio Soto‐Añari, Leonel Tadao Takada, Lea Tenenholz Grinberg, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Dominic Trépel, Agustin Ibanez. Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Daniel J Klionsky, Amal Kamal Abdel-Aziz, [], Claudio Hetz, [], Chun-Kit Tong et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280.

Metacognition of emotion recognition across neurodegenerative diseases. Indira Garcia-Cordero, Joaquín Migeot, Sol Fittipaldi, Alexia Aquino, Cecilia Gonzalez Campo, Adolfo García, Agustín Ibáñez. Cortex. 2021 Apr;137:93-107. doi: 10.1016/j.cortex.2020.12.023.

Dynamic brain fluctuations outperform connectivity measures and mirror pathophysiological profiles across dementia subtypes: A multicenter study. Sebastian Moguilner, Adolfo M García, Yonatan Sanz Perl, Enzo Tagliazucchi, Olivier Piguet, Fiona Kumfor, Pablo Reyes, Diana Matallana, Lucas Sedeño, Agustín Ibáñez. Neuroimage. 2021 Jan 15;225:117522. doi: 10.1016/j.neuroimage.2020.117522.

Simultaneous determination of intraluminal lysosomal calcium and pH by dextran-conjugated fluorescent dyes. Philippe Pihán, Paula Nunes-Hasler, Nicolas Demaurex, Claudio Hetz. Methods Cell Biol. 2021;165:199-208. doi: 10.1016/bs.mcb.2021.02.007.

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration. René L Vidal, Denisse Sepulveda, Paulina Troncoso-Escudero, Paula Garcia-Huerta, Constanza Gonzalez, Lars Plate, Carolina Jerez, José Canovas, Claudia A Rivera, Valentina Castillo, Marisol Cisternas, Sirley Leal, Alexis Martinez, Julia Grandjean, Donzelli Sonia, Hilal A Lashuel, Alberto J M Martin, Veronica Latapiat, Soledad Matus, S Pablo Sardi, R Luke Wiseman, Claudio Hetz. Mol Ther. 2021 Feb 3;S1525-0016(21)00067-8. doi: 10.1016/j.ymthe.2021.01.033

Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS. Pablo Rozas, Cristina Pinto, Francisca Martínez Traub, Rodrigo Díaz, Viviana Pérez, Daniela Becerra, Patricia Ojeda, Jorge Ojeda, Madison T Wright, Jessica Mella, Lars Plate, Juan Pablo Henríquez, Claudio Hetz, Danilo B Medinas. Acta Neuropathol Commun. 2021 Feb 4;9(1):21. doi: 10.1186/s40478-020-01116-z.

Therapeutic potential of insulin-like growth factor 2 in Huntington’s disease: controlling proteostasis to alleviate the load of misfolded protein. Paulina Troncoso-Escudero, Claudio Hetz, Rene L Vidal. Neural Regen Res. 2021 Aug;16(8):1564-1565. doi: 10.4103/1673-5374.303020.

DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer’s Disease Patients and a Transgenic Model of the Disease. Esteban Leyton, Diego Matus, Sandra Espinoza, José Matías Benitez, Bastián I Cortes, Wileidy Gomez, Nohela B Arévalo, Paola Murgas, Patricio Manque, Ute Woehlbier, Claudia Duran-Aniotz, Claudio Hetz, María Isabel Behrens, Carol D SanMartín, Melissa Nassif. J Alzheimers Dis. 2021 Feb 19. doi: 10.3233/JAD-201264.

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases. Jun Ren, Yaguang Bi, James R Sowers, Claudio Hetz, Yingmei Zhang. Nat Rev Cardiol. 2021 Feb 22. doi: 10.1038/s41569-021-00511-w.

The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science. Agustin Ibanez, Jennifer S Yokoyama, Katherine L Possin, Diana Matallana, Francisco Lopera, Ricardo Nitrini, Leonel T Takada, Nilton Custodio, Ana Luisa Sosa Ortiz, José Alberto Avila-Funes, Maria Isabel Behrens, Andrea Slachevsky, Richard M Myers, J Nicholas Cochran, Luis Ignacio Brusco, Martin A Bruno, Sonia M D Brucki, Stefanie Danielle Pina-Escudero, Maira Okada de Oliveira, Patricio Donnelly Kehoe, Adolfo M Garcia, Juan Felipe Cardona, Hernando Santamaria-Garcia, Sebastian Moguilner, Claudia Duran-Aniotz, Enzo Tagliazucchi, Marcelo Maito, Erika Mariana Longoria Ibarrola, Maritza Pintado-Caipa, Maria Eugenia Godoy, Vera Bakman, Shireen Javandel, Kenneth S Kosik, Victor Valcour, Bruce L Miller. Front Neurol. 2021 Mar 11;12:631722. doi: 10.3389/fneur.2021.631722.

Adapting the proteostasis capacity to sustain brain healthspan. Claudio Hetz. Cell. 2021 Mar 18;184(6):1545-1560. doi: 10.1016/j.cell.2021.02.007.

Retinal Ganglion Cells Functional Changes in a Mouse Model of Alzheimer’s Disease Are Linked with Neurotransmitter Alterations. Joaquín Araya, Felipe Bello, Gaganashree Shivashankar, David Neira, Claudia Durán-Aniotz, Mónica L Acosta, María José Escobar, Claudio Hetz, Max Chacón, Adrián G Palacios. J Alzheimers Dis. 2021 Mar 13. doi: 10.3233/JAD-201195.

Impact of Social Isolation on People with Dementia and Their Family Caregivers. Lílian Viana Dos Santos Azevedo, Ismael Luis Calandri, Andrea Slachevsky, Héctor Gastón Graviotto, Maria Carolina Santos Vieira, Caíssa Bezerra de Andrade, Adriana Peredo Rossetti, Alana Barroso Generoso, Karoline Carvalho Carmona, Ludmilla Aparecida Cardoso Pinto, Marcos Sorbara, Alejandra Pinto, Tania Guajardo, Loreto Olavarria, Daniela Thumala, Lucía Crivelli, Ludmila Vivas, Ricardo Francisco Allegri, Maira Tonidandel Barbosa, Cecilia M Serrano, Claudia Miranda-Castillo, Paulo Caramelli. J. Alzheimers Dis. 2021 Mar 30. doi: 10.3233/JAD-201580.

In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca 2+ Fluxes. Ulises Ahumada-Castro, Galdo Bustos, Eduardo Silva-Pavez, Andrea Puebla-Huerta, Alenka Lovy, César Cárdenas. Front Cell Dev Biol. 2021 Mar 2;9:629522. doi: 10.3389/fcell.2021.629522

Interoception primes emotional processing: Multimodal evidence from neurodegeneration. Paula C. Salamone, Agustina Legaz, Lucas Sedeño, Sebastián Moguilner, Matías Fraile-Vazquez, Cecilia Gonzalez Campo, Sol Fittipaldi, Adrián Yoris, Magdalena Miranda, Agustina Birba, Agostina Galiani, Sofía Abrevaya, Alejandra Neely, Miguel Martorell Caro, Florencia Alifano, Roque Villagra, Florencia Anunziata, Maira Okada de Oliveira, Ricardo M. Pautassi, Andrea Slachevsky, Cecilia Serrano, Adolfo M. García and Agustín Ibañez. Journal of Neuroscience 7 April 2021, JN-RM-2578-20. DOI: https://doi.org/10.1523/JNEUROSCI.2578-20.2021

Neuron-intrinsic origin of hyperexcitability during early pathogenesis of Alzheimer’s disease: An Editorial Highlight for “Hippocampal hyperactivity in a rat model of Alzheimer’s disease” on https://doi.org/10.1111/jnc.15323. Dasfne Lee-Liu, Christian Gonzalez-Billault. J Neurochem. 2021 Apr 28. DOI: 10.1111/jnc.15248

The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America. Ganesh M Babulal, Valeria L Torres, Daisy Acosta, Cinthya Agüero, Sara Aguilar-Navarro, Rebecca Amariglio, Juliana Aya Ussui, Ana Baena, Yamile Bocanegra 5, Sonia Maria Dozzi Brucki, Julian Bustin, Diego M Cabrera, Nilton Custodio, Monica M Diaz, Lissette Duque Peñailillo, Idalid Franco, Jennifer R Gatchel, Ana Paola Garza-Naveda, Mariana González Lara, Lidia Gutiérrez-Gutiérrez, Edmarie Guzmán-Vélez, Bernard J Hanseeuw, Ivonne Z Jimenez-Velazquez, Tomás León Rodríguez, Jorge Llibre-Guerra, María J Marquine, Jairo Martinez, Luis D Medina, Claudia Miranda-Castillo, Alejandra Morlett Paredes, Diana Munera, Alberto Nuñez-Herrera, Maira Okada de Oliveira, Santiago J Palmer-Cancel, Enmanuelle Pardilla-Delgado, Jaime Perales-Puchalt, Celina Pluim, Liliana Ramirez-Gomez, Dorene M Rentz, Claudia Rivera-Fernández, Monica Rosselli, Cecilia M Serrano, Maria Jose Suing-Ortega, Andrea Slachevsky, Marcio Soto-Añari, Reisa A Sperling, Fernando Torrente, Daniela Thumala, Patrizia Vannini, Clara Vila-Castelar, Tatiana Yañez-Escalante, Yakeel T Quiroz. EClinicalMedicine. 2021 Apr 27;35:100848. doi: 10.1016/j.eclinm.2021.100848.

Building brain capital. Harris A Eyre, Rym Ayadi, William Ellsworth, Gowri Aragam, Erin Smith, Walter D Dawson, Agustin Ibanez, Cara Altimus, Michael Berk, Husseini K Manji, Eric A Storch, Marion Leboyer, Naoko Kawaguchi, Michael Freeman, Patrick Brannelly, Facundo Manes, Sandra B Chapman, Jeffrey Cummings, Carol Graham, Benjamin F Miller, Zoltan Sarnyai, Retsina Meyer, William Hynes. Neuron. 2021 May 5;109(9):1430-1432. doi: 10.1016/j.neuron.2021.04.007.

Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders. Danilo B Medinas, Younis Hazari, Claudio Hetz. Prog Mol Subcell Biol. 2021;59:239-278. doi: 10.1007/978-3-030-67696-4_12.

DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer’s Disease Patients, and a Transgenic Model of the Disease. Esteban Leyton, Diego Matus, Sandra Espinoza, José Matías Benitez, Bastián I Cortés, Wileidy Gomez, Nohela B Arévalo, Paola Murgas, Patricio Manque, Ute Woehlbier, Claudia Duran-Aniotz, Claudio Hetz, María Isabel Behrens, Carol D SanMartín, Melissa Nassif. Journal of Alzheimer’s Disease, vol. 82, no. s1, pp. S163-S178, 2021. DOI: 10.3233/JAD-201264

Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries. Claudia Duran-Aniotz, Paulina Orellana, Tomas Leon Rodriguez, Fernando Henriquez, Victoria Cabello, María F Aguirre-Pinto, Tamara Escobedo, Leonel T Takada, Stefanie D Pina-Escudero, Oscar Lopez, Jennifer S Yokoyama, Agustin Ibanez, Mario A Parra, Andrea Slachevsky. Front Neurol. 2021 Jun 24;12:663407. doi: 10.3389/fneur.2021.663407.

The Latin America and the Caribbean Consortium on Dementia (LAC-CD): From Networking to Research to Implementation Science. Agustin Ibanez, Mario A Parra, Christopher Butler. J Alzheimers Dis. 2021;82(s1):S379-S394. doi: 10.3233/JAD-201384.

A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington’s disease. Rodrigo Pérez-Arancibia, Jose Luis Ordoñez, Alexis Rivas, Philippe Pihán, Alfredo Sagredo, Ulises Ahumada, Andrés Barriga, Ivette Seguel, César Cárdenas, Rene L Vidal, Claudio Hetz, Carla Delporte. PLoS One. 2021 Jul 29;16(7):e0254834. doi: 10.1371/journal.pone.0254834.

Predicting and Characterizing Neurodegenerative Subtypes with Multimodal Neurocognitive Signatures of Social and Cognitive Processes. Agustín Ibañez, Sol Fittipaldi, Catalina Trujillo, Tania Jaramillo, Alejandra Torres, Juan F Cardona, Rodrigo Rivera, Andrea Slachevsky, Adolfo García, Maxime Bertoux , Sandra Baez. J Alzheimers Dis. 2021 Jul 15. doi: 10.3233/JAD-210163.

Rekindling Action Language: A Neuromodulatory Study on Parkinson’s Disease Patients. Diana M A Suárez-García, Agustina Birba, Máximo Zimerman, Jesús A Diazgranados, Pamela Lopes da Cunha, Agustín Ibáñez, Johan S Grisales-Cárdenas, Juan Felipe Cardona, Adolfo M García. Brain Sci. 2021 Jul 1;11(7):887. doi: 10.3390/brainsci11070887.

Therapeutic potential of insulin-like growth factor 2 in Huntington’s disease: controlling proteostasis to alleviate the load of misfolded protein. Paulina Troncoso-Escudero, Claudio Hetz, Rene L Vidal. Neural Regen Res. 2021 Aug;16(8):1564-1565. doi: 10.4103/1673-5374.303020.

Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons. Daniela Vallejo, Carolina B Lindsay, Christian González-Billault, Nibaldo C Inestrosa. J Neurochem. 2021 Aug;158(3):673-693. doi: 10.1111/jnc.15448.

Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain. Elisa Gorostieta-Salas, Daniel Moreno-Blas, Cristian Gerónimo-Olvera, Bulmaro Cisneros, Felipe A Court, Susana Castro-Obregón. Oxid Med Cell Longev. 2021 Aug 13;2021:6682336. doi: 10.1155/2021/6682336.

Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. Eduardo Pulgar, Cornelia Schwayer, Néstor Guerrero, Loreto López, Susana Márquez, Steffen Härtel, Rodrigo Soto, Carl-Philipp Heisenberg, Miguel L Concha. Elife. 2021 Aug 27;10:e66483. doi: 10.7554/eLife.66483.

Evaluating a Memory Clinic Using the RE-AIM Model. The Experience of the “Memory and Neuropsychiatry Clinic” in Hospital Del Salvador, Chile. Tomas Leon, Loreto Castro, Franco Mascayano, Brian Lawlor, Andrea Slachevsky. Front Neurol. 2021 Sep 6;12:612416. doi: 10.3389/fneur.2021.612416.

Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases. Agustina Legaz , Sofía Abrevaya, Martín Dottori, Cecilia González Campo, Agustina Birba, Miguel Martorell Caro, Julieta Aguirre, Andrea Slachevsky, Rafael Aranguiz, Cecilia Serrano, Claire M Gillan, Iracema Leroi, Adolfo M García, Sol Fittipaldi, Agustín Ibañez. Brain. 2021 Sep 16;awab345. doi: 10.1093/brain/awab345.

Dementia with Lewy bodies research consortia: A global perspective from the ISTAART Lewy Body Dementias Professional Interest Area working group. Fabrizia D’Antonio, Joseph P M Kane, Agustin Ibañez, Simon J G Lewis, Richard Camicioli, Huali Wang, Yueyi Yu, Jing Zhang, Yong Ji, Miguel Germán Borda, Rukmini Mridula Kandadai, Claudio Babiloni, Laura Bonanni , Manabu Ikeda, Bradley F Boeve, James B Leverenz, Dag Aarsland, ISTAART. Lewy body dementias Consortia Working Group Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12235. doi: 10.1002/dad2.12235.

Organization of the Catecholaminergic System in the Short-Lived Fish Nothobranchius furzeri. Janina Borgonovo, Patricio Ahumada-Galleguillos, Alejandro Oñate-Ponce, Camilo Allende-Castro, Pablo Henny, Miguel L Concha. Front Neuroanat. 2021 Sep 13;15:728720. doi: 10.3389/fnana.2021.728720.

CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues. Xiaobing Yu, Leonel Munoz-Sagredo, Karolin Streule, Patricia Muschong, Elisabeth Bayer, Romina J Walter, Julia C Gutjahr, Richard Greil, Miguel L Concha, Carsten Müller-Tidow, Tanja N Hartmann, Véronique Orian-Rousseau. Blood. 2021 Sep 23;138(12):1067-1080. doi: 10.1182/blood.2020006343.

Pediatric Extracorporeal Membrane Oxygenation (ECMO) Transport in a Developing Nation: A Single Center Experience. Daniela Martinez, Rodrigo Diaz, Jorge Rufs, Christian Fajardo, Cristián Valverde, Felipe Salech. ASAIO J. 2021 Sep 24. doi: 10.1097/MAT.0000000000001567.

Bacteria and fungi: The counteracting modulators of immune responses to radiation therapy in cancer. Erick Riquelme, Florencia McAllister. Cancer Cell. 2021 Sep 13;39(9):1173-1175. doi: 10.1016/j.ccell.2021.08.004.