PUBLICACIONES 2016

Los estudios desarrollados en nuestro Centro están enfocados en comprender los principios básicos del envejecimiento desde moléculas a sistemas. También buscamos descifrar si la población chilena alberga la mayoría de las propiedades genéticas, moleculares y celulares que se han descrito en cohortes de todo el mundo, o si tiene características únicas.

66 PUBLICACIONES

  • A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2 Release During Axonal Specification, Wilson C, Muñoz-Palma E, Henriquez DR, Palmisano I, Nuñez MT, Di Giovanni S and Gonzalez-Billault C.,Journal of Neuroscience. 2016, 36 (11107-11119)
  • Dissecting the role of redox signaling in neuronal development, Bórquez DA, Urrutia PJ, Wilson C, van Zundert B, Núñez MT, González-Billault C. ,Journal of Neurochemistry. 2016, 137 (506-517) 10.1111/jnc.13581
  • Actin filaments-a target for redox regulation, Wilson C, Terman JR, González-Billault C, Ahmed G.,Cytoskeleton. 2016, 73 (577-595), 10.1002/cm.21315
  • p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer’s disease, Uribe-Arias A, Posada-Duque RA, González-Billault C, Villegas A, Lopera F, Cardona-Gómez GP,Journal of Neurochemistry. 2016, 138 (623-639), 10.1111/jnc.13697
  • CDK5 downregulation enhances synaptic plasticity, Posada-Duque RA, Ramirez O, Härtel S, Inestrosa NC, Bodaleo F, González-Billault C, Kirkwood A, Cardona-Gómez GP.,Cell Molecular Life Sciences. 2016,
  • The presynaptic microtubule cytoskeleton in physiological and pathological conditions: lessons from Drosophila Fragile X Syndrome and ereditary spastic paraplegias, Bodaleo FJ, Gonzalez-Billault C,Frontiers in Molecular Neuroscience. 2016, 9 (60), 10.3389/fnmol.2016.00060
  • Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic hysiology, Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C.,Scientific Reports. 2016, 6 (30069), 10.1038/srep30069
  • Rab35 functions in axon elongation are regulated by p53-related protein kinase in a mechanis that involves Rab35 protein degradation and he microtubule-associated protein 1B, Villarroel-Campos D, Henríquez DR, Bodaleo FJ, Oguchi ME, Bronfman FC, Fukuda M, Gonzalez-Billault C.,Journal of Neuroscience. 2016, 36 (7298-7313), 10.1523/JNEUROSCI.4064-15.2016
  • Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal e-growth, Quintá HR, Wilson C, Blidner AG, González-Billault C, Pasquini LA, Rabinovich GA, Pasquini JM,Experimental Neurology. 2016, 283 (165-178), 10.1016/j.expneurol.2016.06.009
  • Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor, Gonzalez A, Moya-Alvarado G, Gonzalez-Billault C, Bronfman FC,Cytoskeleton. 2016, 73 (612-628), 10.1002/cm.21312
  • Rab GTPase signaling in neurite outgrowth and axon specification, Villarroel-Campos D, Bronfman FC, Gonzalez-Billault C,Cytoskeleton. 2016, 73 (498-507), 10.1002/cm.21303
  • InsP3R, the Calcium Whisperer: Maintaining Mitochondrial Function in Cancer, Lovy, A. Foskett, J.K. and Cardenas2, C.,Molecular Cellular Oncology. 2016, 3 (e1185563), 10.1080/23723556.2016.1185563
  • Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease, Herrera1, A. , Muñoz P., Paris I., Díaz-Veliz G., Mora S., Inzunza J., Hultenby K., Cardenas C., Jaña F., Raisman-Vozari R., Gysling K., Abarca J., Steinbusch HW., Segura-Aguilar2 J.,Cell Mol Life Sci. 2016, 73 (3583-97), 10.1007/s00018-016-2182-5
  • Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae)., Schmeda-Hirschmann3, G., Quispe, C., Arana, GV., Theoduloz, C., Urra, FA., Cárdenas, C.,Toxicon. 2016, 121 (119-129), 10.1016/j.toxicon.2016.09.004
  • Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria., Cárdenas3, C., Muller, M, McNeal, A., Lovy, A., Jaňa, F., Bustos, G., Smith, N., Molgo, J., Diehl, A., Ridky, TW., and Foskett J.K.,Cell Rep. 2016, 14 (2313-24), 10.1016/j.celrep.2016.02.030
  • Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve., Carolina González, José Cánovas, Javiera Fresno, Eduardo Couve, Felipe A. Court, and Andrés Couve,PNAS. 2016, 113 (1823-1828), 10.1073/pnas.1514943113
  • Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury., Maritza Oñate1, Alejandra Catenaccio, Gabriela Martínez, Donna Armentano, Geoffrey Parsons, Bredford Kerr, Claudio Hetz2 & Felipe A. Court2,Scientific reports. 2016, 6 (21709), 10.1038/srep21709
  • Schwann Cell Exosomes Mediate Neuron–Glia Communication and Enhance Axonal Regeneration., Rodrigo Lopez-Leal1, Felipe A. Court2,Cell Molecular Neurobiology. 2016, 36 (429-436), 10.1007/s10571-015-0314-3.
  • Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury. , Margarita Calvo3, Natalie Richards, Annina B Schmid, Alejandro Barroso, Lan Zhu, Dinka Ivulic, Ning Zhu, Philipp Anwandter, Manzoor A Bhat, Felipe A Court, Stephen B McMahon, David LH Bennett2,eLife. 19 (e12661),10.7554/eLife.12661.
  • Injury to the nervous system: A look into the ER., Vicente Valenzuela1, Maritza Oñate, Claudio Hetz2, Felipe A. Court2, Brain Res. 2016, 1648 (617-625), 10.1016/j.brainres.2016.04.053
  • Bursting the unfolded protein response accelerates axonal regeneration. Neural Regen Res., Oñate M1, Court FA2, Hetz C2,Neural Regeneration research. 2016, 11 (892-893), 10.4103/1673-5374.184453.
  • Schwann Cell and Axon: An Interlaced Unit-From Action Potential to Phenotype Expression., Court FA3, Alvarez J.,Adv Exp Med Biol. 2016, 949 (183-201), 10.1007/978-3-319-40764-7_9
  • Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium? , López-Leal R1, Alvarez J, Court FA2,Cytoskeleton. 2016, 73 (629-639), 10.1002/cm.21319
  • Regulation of Memory Formation by the Transcription Factor XBP1, Gabriela Martínez, Rene L. Vidal, Pablo Mardones, Nibaldo C. Inestrosa, Laurie H. Glimcher, Claudio Hetz,Cell Reports. 2016, 14 (1382-1394), 10.1016/j.celrep.2016.01.028
  • ALS-linked Protein Disulfide Isomerase Variants cause motor dysfunction, Woehlbier U, Colombo A, Saaranen M, Pérez V., Ojeda J., Bustos F., Andreu C., Torres M., Valenzuela V., Medinas D., Rozas P., Vidal R., Lopez-Gonzalez R., Salameh J., Fernandez-Collemann S., Muñoz N., Matus S., Armisen R., Sagredo A., Palma K., Irrazabal T., Gonzalez-Perez P., Campero M., Gao F, Henny P., van Zundert B., Ruddock L., Concha M., Henriquez J., Brown R.H. and Hetz C,EMBO J. 2016, 35 (845-65), 10.15252/embj.201592224
  • Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anti-cancer agent, 4. Xiang M, Kim H, Ho VT, Walker SR, Bar-Natan M, Anahtar M, Liu S, Toniolo PA, Kroll Y, Jones N, Giaccone ZT, Heppler LN, Ye DQ, Marineau JJ, Shaw D, Bradner JE, Blonquist T, Neuberg D, Hetz C, Stone RM, Soiffer RJ, and Frank DA,Blood. 2016, 10.1182/blood-2015-07-660506
  • NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation, Mathieu Nivona, Loïc Forta, Pascale Mullera, Emma Richeta, Stéphanie Simona, Baptiste Gueya, Maëlenn Fourniera, André-Patrick Arrigoa, Claudio Hetzc, Julie D. Atkine, and Carole Kretz-Remya,MBoC. 2016, 27 (1712-27), 10.1091/mbc.E15-12-0835
  • Creutzfeldt-Jakob disease. Report of one case, Ramírez M., Gallardo A., Cornejo A., Vidal A., Ramírez D., Medinas D., Hetz C., Bustamante G., Pasquali R.,Revista Médica de Chile. 2016, 144 (6), 10.4067/S0034-98872016000600016.
  • PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response, AnanyaGupta, Muhammad Mosaraf Hossain, Danielle E. Read, Claudio Hetz, Afshin Samali & SanjeevGupta,Scientific Reports. 2016, 5 (18304), 10.1038/srep18304.
  • ER stress and the hallmarks of cancer, Urra H., Dufey E., Avril T., Chevet E. and Hetz C,Trends in Cancer. 2016, 5 (252-262),
  • Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport, Mardones P., Rubinztein D. and Hetz C,Science Signaling. 2016, 9(416), 10.1126/scisignal.aaf1937
  • Divergent roles of ER stress in neurodegeneration and brain disorders,Hetz C. and Saxena S., Brain Res. 2016, 1648 (527-529), 10.1016/j.brainres
  • The ER proteostasis network in ALS: explaining the differential motoneuron vulnerability, Rozas P., Bargsted L., Martínez F., Hetz C. and Medinas D.B. ,Neuroscience Letters. 2016, S0304-3940(16)30288 (9), 10.1016/j.neulet
  • The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases., Paula Garcia-Huerta, Paulina Troncoso-Escudero, Carolina Jerez, Claudio Hetz and Rene L. Vidal,Brain Res. 2016, 1649 (173-180), 10.1016/j.brainres.2016.02.052
  • ERp57 as a novel cellular factor controlling Prion biosynthesis: Therapeutic potential of protein disulfide isomerases, Sepulveda M., Rozas P., Hetz C. and Medinas D. ,Prion. 29016, 10 (50-56), 10.1080/19336896
  • Guidelines for the use and interpretation of assays for monitoring autophagy(2nd edition). ,Klionsky et al (Hetz C) , Autophagy. 2016, 12:01 (222), 10.1080/15548627.2015.1100356
  • Gene therapy to target ER stress in brain diseases, Vicente Valenzuela, Gabriela Martínez, Claudia Duran-Aniotz and Claudio Hetz,Brain Res. 2016, 1648 (561-570), 10.1016/j.brainres
  • Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations, Mollereau B, Roussel B.D., Chevet E., Sedru M., Van den Brink D., Bailly-Maitre B., Palladino F., Medinas D.B.,Domingos P.M., Hunot S., Chandran S., Rzechorzek N.M., Birman S., Baron T., Vivien D., Duarte C.B., Ryoo H.D.., Crowder C.M., Urano F., Steller H., Kroemer G., Ciechanover A., Calabrese E., Kaufman R.J. and Hetz C.,Brain Res. 2016, 1648 (603–616), 10.1016/j.brainres
  • ERp57 in neurodegeneration and regeneration, Leslie Bargsted, Claudio Hetz and Soledad Matus,Neural Regen Res. 2016, 11(2) (232–233), 10.4103/1673-5374.177722
  • Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity, Martínez G, Duran-Aniotz C, Cabral-Miranda F, and Hetz C,Front Aging Neurosci. 2916, 8 (12),  10.3389/fnagi.2016.00182
  • Glucose metabolism: A Sweet relief of Alzheimer´s disease,Duran-Aniotz C. and Hetz C, Current Biol. 2016, 26 (R806–R809), 10.1016/j.cub.2016.07.060.
  • Targeting ER acetylation to restore proteostasis in Alzheimer’s disease, Duran-Aniotz C., Cornejo V., and Hetz C,Brain. 2016, 139 (650-652), 101.093
  • Comparison of the psychometric properties of the “Word” and “Picture” Versions of the Free and Cued Selective Reminding Test in a panish-speaking cohort of patients with mild Alzheimer’s disease and cognitively healthy controls., Delgado C,; Muñoz-Neira C.; Soto A,; Martinez M Henriquez F; Flores P, Slachevsky A,Archives of Clinical Neuropsychology
  • Neuropsychiatric Characteristics of Alzheimer’s Disease and the Behavioral Variant of Frontotemporal Dementia, Muñoz-Neira C., Slachevsky A., López Oscar L.,JSM Alzheimer’s Dis Related Dementia. 2016, 3 (1023),
  • Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia, Baez S., Morales Juan P., Slachevsky A., Torralva T., Matus C., Manes F., Ibanez A.,Cortex. 2016, 75 (20-32), 10.1016/j.cortex.2015.11.007
  • Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures, Baez S., Kanske P., Matallana D., Montañez P., Reyes P., Slachevsky A., Matus C., Viglieca N. S., Torralva T., Manes F., Ibanez A. ,Neurodegener Dis. 2016, 16 (206-217), 10.1159/000441918
  • Heterochrony and Morphological Variation of Epithalamic Asymmetry, SIGNORE, ISKRA A.; CONCHA, MIGUEL L.,Journal of Experimental Zoology Part B: Molecular and Developmental Evolution,10.1002/jez.b.22698
  • Directional asymmetry in the volume of the human habenula,Ahumada-Galleguillos P.; Lemus C.G.; Diaz E.; Osorio-Reich M.; Härtel S.; oncha M.L.,Brain Structure and Function,10.1007/s00429-016-1231-z
  • Nodal signalling and asymmetry of the nervous system, Iskra A. Signore, Karina Palma, Miguel L. Concha,Philosophical Transactions of the Royal Society B,10.1098/rstb.2015.0401
  • ER chaperones in neurodegenerative disease: Folding and beyond, Garcia-Huerta P., Bargsted L., Rivas A., Matus S., Vidal R. , Brain Res. 2016, 1648(Pt B) (580-587), 10.1016/j.brainres.2016.04.070
  • ALS-linked Protein Disulfide Isomerase Variants cause motor dysfunction, Woehlbier U, Colombo A, Saaranen M, Pérez V., Ojeda J., Bustos F., Andreu C., Torres M., Valenzuela V., Medinas D., Rozas P., Vidal R., Lopez-Gonzalez R., Salameh J., Fernandez-Collemann S., Muñoz N., Matus S., Armisen R., Sagredo A., Palma K., Irrazabal T., Gonzalez-Perez P., Campero M., Gao F, Henny P., van Zundert B., Ruddock L., Concha M., Henriquez J., Brown R.H. and Hetz C,EMBO J. 2016, 35 (845-65), 10.15252/embj.201592224
  • The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases., Paula Garcia-Huerta, Paulina Troncoso-Escudero, Carolina Jerez, Claudio Hetz and Rene L. Vidal,Brain Res. 2016, 1649 (173-180), 10.1016/j.brainres.2016.02.052
  • ALS-linked Protein Disulfide Isomerase Variants cause motor dysfunction, Woehlbier U, Colombo A, Saaranen M, Pérez V., Ojeda J., Bustos F., Andreu C., Torres M., Valenzuela V., Medinas D., Rozas P., Vidal R., Lopez-Gonzalez R., Salameh J., Fernandez-Collemann S., Muñoz N., Matus S., Armisen R., Sagredo A., Palma K., Irrazabal T., Gonzalez-Perez P., Campero M., Gao F, Henny P., van Zundert B., Ruddock L., Concha M., Henriquez J., Brown R.H. and Hetz C,EMBO J. 2016, 35 (845-65), 10.15252/embj.201592224
  • ERp57 in neurodegeneration and regeneration, Leslie Bargsted, Claudio Hetz and Soledad Matus,Neural Regen Res. 2016, 11(2) (232–233), 10.4103/1673-5374.177722
  • Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration, J. Richardson, A. Gauert, L. Briones Montecinos, L. Fanlo, Z. M. Alhashem, R. Assar, E. Marti, A. Kabla, S. HŠrtel, C. Linker,Cell Reports. 2016, 15 (2076-2088), 10.1016/j.celrep.2016.04.067
  • Dementia in Latin America: An emergent silent tsunami,Baez S and Ibanez A, Front. Aging Neurosci. 2016, 8 (253), 10.3389/fnagi.2016.00253
  • The cerebellum and embodied semantics: Evidence from a case of genetic ataxia due to STUB1 mutations, García AM, Abrevaya S, Kozono G, García-Cordero I, Córdoba M, Kauffman MA, Pautassi R, Muñoz E, Sedeño L, Ibáñez A, Journal of Medical Genetics,10.1136/jmedgenet-2016-104148
  • The road less traveled: Alternative pathways for action-verb processing in Parkinson’s disease, Abrevaya S, Sedeño L, Fitipaldia S, Pineda D, Lopera F,Buritica O, Villegas A, Bustamante C, Gomez D, Trujillo N, Pautassi R, Ibáñez R, García AM, Journal of Alzheimer’s Disease,10.3233/JAD-160737
  • Social neuroscience: Undoing the schism between neurology and psychiatry,Ibanez A; Garcia A; Esteves S; Yoris A; Edinson M; Reynaldo L; ietto M; Adolfi F; Manes F.,Social Neuroscience,10.1080/17470919.2016.1245214
  • Language Deficits as a Preclinical Window into Parkinson’s Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation arriers, García AM, Sedeño L, Trujillo N, Bocanegra Y, Gomez D, Pineda D, Villegas A, Muñoz E, Arias W, Ibáñez A., Journal of the International Neuropsychological Society
  • How language flows when movements don’t: An automated analysis of spontaneous discourse in Parkinson’s disease, García, A. M., Carrillo, F., Orozco-Arroyave, J. R., Trujillo, N., Vargas Bonilla, J. F., Fittipaldi, S., Adolfi, F., Nöth, E., Sigman, M., Fernández Slezak, D., Ibáñez, A. & Cecchi, G. A.,Brain and Language. 2016, 162 (19-28), 10.1016/j.ijpsycho.2016.07.338
  • Your misery is no longer my pleasure: Reduced schadenfreude in Huntington’s disease families, Baez S, Santamaría-García H, Orozco J, Fittipaldi S, García AM, Pino M, Ibáñez A.,Cortex. 2016, 83 (78-85), 10.1016/j.bandl.2016.07.008
  • Behavioral and Electrophysiological Correlates of Memory Binding Deficits in Patients at Different Risk Levels for Alzheimer’s isease, Pietto M, Parra MA, Trujillo N, Flores F, García AM, Bustin J, Richly P, Manes F, Lopera F, Ibáñez A, Baez S.,J Alzheimers Dis. 2016, 30 (53-54), 10.1016/j.cortex.2016.07.009
  • Feeling, learning from, and being aware of inner states: Interoceptive dimensions in neurodegeneration and stroke., García-Cordero I, Sedeño L, de la Fuente L , Slachevsky A, Forno G, Klein F, Lillo P, Ferrari J, Rodriguez C, Bustin J, Torralva T, Baez S, Yoris A, Esteves S, Melloni M, Salamone P, Huepe D, Manes F, García A, Ibañez A., Phil. Trans. R. Soc. B.,10.3233/JAD-160056
  • The social context network model in psychiatric and neurological diseases, Baez S, García AM, Ibáñez A., TopBehav Neurosci,10.1098/rstb.2016-0006
  • Feeling, learning from, and being aware of inner states: Interoceptive dimensions in neurodegeneration and stroke., García-Cordero I, Sedeño L, de la Fuente L , Slachevsky A, Forno G, Klein F, Lillo P, Ferrari J, Rodriguez C, Bustin J, Torralva T, Baez S, Yoris A, Esteves S, Melloni M, Salamone P, Huepe D, Manes F, García A, Ibañez A.,Phil. Trans. R. Soc. B. 2016, 33 (16657-16665), 10.1007/7854_2016_443