PUBLICACIONES 2022

Los estudios desarrollados en nuestro Centro están enfocados en comprender los principios básicos del envejecimiento desde moléculas a sistemas. También buscamos descifrar si la población chilena alberga la mayoría de las propiedades genéticas, moleculares y celulares que se han descrito en cohortes de todo el mundo, o si tiene características únicas.

 

SEPTIEMBRE 2022

  • Neuronal activity-dependent ATP enhances the pro-growth effect of repair Schwann cell extracellular vesicles by increasing their miRNA-21 loading. Cristian Saquel , Romina J Catalan, Rodrigo Lopez-Leal, Ramon A Ramirez, David Necuñir, Ursula Wyneken, Christophe Lamaze, Felipe A Court. Front Cell Neurosci. 2022 Sep 23;16:943506. DOI: 10.3389/fncel.2022.943506
  • Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer’s Association Global Consortium. Gabriel A de Erausquin, Heather Snyder, Traolach S Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, (…), Agustín Ibáñez, (…), Farhaan S Vahidy. Alzheimers Dement (N Y). 2022 Sep 22;8(1):e12348. DOI: 10.1002/trc2.12348
  • Biomarkers for dementia in Latin American countries: Gaps and opportunities. Mario A Parra, Paulina Orellana, Tomas Leon, Cabello G Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibañez, (…) Claudia Duran-Aniotz. Alzheimers Dement. 2022 Sep 13. DOI: 10.1002/alz.12757

AGOSTO 2022

  • Multi-feature computational framework for combined signatures of dementia in underrepresented settings. Sebastian Moguilner, Agustina Birba, Sol Fittipaldi, Cecilia Gonzalez-Campo, Enzo Tagliazucchi, Pablo Reyes, Diana Matallana, Mario A Parra, Andrea Slachevsky, Gonzalo Farías, Josefina Cruzat, Adolfo García, Harris A Eyre, Renaud La Joie, Gil Rabinovici, Robert Whelan, Agustín Ibáñez. Journal of Neural Engineering. 19(4). 2022 Aug 25.
  • Toward a Brain Capital Living Lab model: multi-scale opportunities. Harris A Eyre, Erin Smith, Agustin Ibanez, Michael Berk. Braz J Psychiatry. 2022 Aug 23.
  • Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease. Felipe Salech, Carol D SanMartín, Jorge Concha-Cerda, Esteban Romero-Hernández, Daniela P Ponce, Gianella Liabeuf, Nicole K Rogers, Paola Murgas, Bárbara Bruna, Jamileth More, María I Behrens. International Journal of Molecular Science, 23(16):9387. 2022 Aug 20.

 

JULIO 2022

  • Balancing energy and protein homeostasis at ER-mitochondria contact sites. Amado Carreras-Sureda, Guido Kroemer, Julio Cesar Cardenas, Claudio Hetz. Sci Signal. 15(741):eabm7524, 2022 Jul 5. DOI: 10.1126/scisignal.abm7524
  • Critical roles of protein disulfide isomerases in balancing proteostasis in the nervous system. Danilo B Medinas, Pablo Rozas, Claudio Hetz. J Biol Chem. 298(7):102087, 2022 Jul. DOi: 10.1016/j.jbc.2022.102087
  • Equity and balance in applied dementia research: A charter of conduct and checklist for global collaborations. Iracema Leroi, Wambui Karanja, Emily R Adrion, Suvarna Alladi, Nilton Custodio, S P Goswami, Maëlenn Guerchet, Jennie Gubner, Agustin Ibanez, Stefania Ilinica, Hussain Jafri, Brian Lawlor, Aya Ashour Mohamed, Adesola Ogunniyi, Ian Robertson, Louise Robinson, Aimee Spector, Mathew Varghese, Wendy Weidner, Paulo Caramelli, Dementia Charter of Conduct Global Expert Reference Group. Int J Geriatr Psychiatry. 37(7), 2022 Jul. DOI: 10.1002/gps.5762.
  • Does culture shape our understanding of others’ thoughts and emotions? An investigation across 12 countries. François Quesque, Antoine Coutrot, Sharon Cox, Leonardo Cruz de Souza, Sandra Baez, (…), Patricia Lillo, Antônio Lúcio Teixeira, Paulo Caramelli, Carol Hudon, Andrea Slachevsky, Agustin Ibáñez, Michael Hornberger, Maxime Bertoux. Neuropsychology. Ahead of print. 2022 Jul 14. DOI: 10.1037/neu0000817
  • The effect of rapamycin and its analogues on age-related musculoskeletal diseases: a systematic review. Hong Lin, Felipe Salech, Anthony Lim, Sara Vogrin, Gustavo Duque. Aging Clin Exp Res. Ahead of print. 2022 Jul 21. DOI: 10.1007/s40520-022-02190-0

 

JUNIO 2022

  • The Latin American Brain Health Institute, a regional initiative to reduce the scale and impact of dementia. Claudia Duran-Aniotz, Jorge Sanhueza, Lea T Grinberg, Andrea Slachevsky, Victor Valcour, Ian Robertson, Brian Lawlor, Bruce Miller, Agustín Ibáñez. Alzheimers Dement. 2022 Jun 16. DOI: 10.1002/alz.12710
  • Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer’s Disease. Sandra Espinoza, Felipe Grunenwald, Wileidy Gomez, Felipe García, Lorena Abarzúa-Catalan, Sebastián Oyarce-Pezoa, Maria Fernanda Hernandez, Bastián I Cortés, Markus Uhrig, Daniela P Ponce, Claudia Durán-Aniotz, Claudio Hetz, Carol D SanMartín, Victor H Cornejo, Fernando Ezquer, Valentina Parra, Maria Isabel Behrens, Patricio A Manque, Diego Rojas-Rivera, René L Vidal, Ute Woehlbier, Melissa Nassif. Cells. 2022 Jun 7;11(12):1860. DOI: 10.3390/cells11121860

 

MAYO 2022

  • Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases. Yiran E Li, James R Sowers, Claudio Hetz, Jun Ren. Cell Death & Disease. 2022 May 27;13(5):504. DOI: 10.1038/s41419-022-04942-2 
  • A chosen STING with a PERKy trail. Younis Hazari & Claudio Hetz. Nature Cell Biology. 2022 May;24(5):602-604. DOI: 10.1038/s41556-022-00905-z.
  • Investing in Late-Life Brain Capital. Walter D Dawson, Erin Smith, Laura Booi, Maia Mosse, Helen Lavretsky, Charles F Reynolds 3rd, Jeffrey Cummings, Patrick Brannally, William Hynes, Eric J Lenze, Facundo Manes, Rym Ayadi, Lori Frank, Sandra Bond Chapman, Ian H Robertson, Lori Rubenstein, Jorge Jraissati, Agustin Ibáñez, Howard Fillit, Dilip V Jeste , Anitha Rao, Michael Berk, Eric A Storch, Antonella Santuccione Chadha, Harris A Eyre. Innovations in Aging. 2022 May 18;6(3):igac016. DOI: 10.1093/geroni/igac016
  • Treatment effects on event-related EEG potentials and oscillations in Alzheimer’s disease. Görsev Yener, Duygu Hünerli-Gündüz, Ebru Yıldırım, Tuba Aktürk, Canan Başar-Eroğlu, Laura Bonanni, Claudio Del Percio, Francesca Farina, Raffaele Ferri, Bahar Güntekin, Mihály Hajós, Agustín Ibáñez, Yang Jiang, Roberta Lizio, Susanna Lopez, Giuseppe Noce, Mario Parra, Fiona Randall, Fabrizio Stocchi, Claudio Babiloni. Int J Psychophysiol. 2022 May 16;S0167-8760(22)00128-3. DOI: 10.1016/j.ijpsycho.2022.05.008
  • Proteostasis and resilience: on the interphase between individual’s and intracellular stress. Mei-Li Díaz-Hung, Claudio Hetz. Trends in endrocrinology and metabolism: TEM. 2022 May;33(5):305-317. DOI: 10.1016/j.tem.2022.02.003
  • Effects of classic psychedelic drugs on turbulent signatures in brain dynamics. Josephine Cruzat, Yonatan Sanz Perl, Anira Escrichs, Jakub Vohryzek, Christopher Timmermann, Leor Roseman, Andrea I. Luppi, Agustin Ibañez, David Nutt, Robin Carhart-Harris, Enzo Tagliazucchi, Gustavo Deco, Morten L. Kringelbach. Network Neuroscience May 2022. DOI: 10.1162/netn_a_00250
  • Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients. Jessica Gallina, Marco Zanon, Ezequiel Mikulan, Mattia Pietrelli, Silvia Gambino, Agustín Ibáñez, Caterina Bertini. Brain Struct Funct. 2022 May 19. DOI: 10.1007/s00429-022-02502-0
  • Multiple events case-control study in a prospective cohort to identify systemic, cellular, and molecular biomarkers of obesity-induced accelerated aging in 30-years-olds: the ObAGE study protocol. P Correa-Burrows, R Burrows, C Albala, F A Court, F Salech, G Sanhueza, C Gonzalez-Billault. BMC Geriatr. 2022 May 2;22(1):387. DOI: 10.1186/s12877-022-03032-4.

 

ABRIL 2022

  • Emerging roles of endoplasmic reticulum proteostasis in brain development. Giselle Espinosa Vásquez, Danilo B Medinas, Hery Urra, Claudio Hetz. Cells & Development Apr 25;170:203781. DOI: 10.1016/j.cdev.2022.20378
  • Socioeconomic status impacts cognitive and socioemotional processes in healthy ageing. Joaquín Migeot, Mariela Calivar, Hugo Granchetti, Agustín Ibáñez, Sol Fittipaldi. Scientific Reports 2022 Apr 11;12(1):6048. DOI: 10.1038/s41598-022-09580-4.
  • Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring. Daniela Elgueta, Paola Murgas, Erick Riquelme, Guang Yang, Gonzalo I Cancino. Frontiers in Inmunology 2022 Apr 7;13:816619. DOI: 10.3389/fimmu.2022.816619
  • Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases. Agustina Legaz, Sofía Abrevaya, Martín Dottori, Cecilia González Campo, Agustina Birba, Miguel Martorell Caro, Julieta Aguirre, Andrea Slachevsky, Rafael Aranguiz, Cecilia Serrano, Claire M Gillan, Iracema Leroi, Adolfo M García, Sol Fittipaldi, Agustín Ibañez. Brain. 2022 Apr 29;145(3):1052-1068. DOI: 10.1093/brain/awab345.

 

MARZO 2022

  • Decoding motor expertise from fine-tuned oscillatory network organization. Lucia Amoruso, Sandra Pusil, Adolfo Martín García, Agustín Ibañez. Hum Brain Mapp. 2022 Mar 11. DOI: 10.1002/hbm.25818
  • Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease. Natalia Salvadores, Ines Moreno-Gonzalez, Nazaret Gamez, Gabriel Quiroz, Laura Vegas-Gomez, Marcela Escandón, Sebastian Jimenez, Javier Vitorica, Antonia Gutierrez, Claudio Soto, Felipe A Court. Acta Neuropathol Commun. 2022 Mar 9;10(1):31. DOI: 10.1186/s40478-022-01332-9.
  • Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia. Mariano N Díaz-Rivera, Agustina Birba, Sol Fittipaldi, Débora Mola, Yurena Morera, Manuel de Vega, Sebastian Moguilner, Patricia Lillo, Andrea Slachevsky, Cecilia González Campo, Agustín Ibáñez, Adolfo M García. Cereb Cortex. 2022 Mar 7;bhac074. DOI: 10.1093/cercor/bhac074

 

FEBRERO 2022

  • Allostatic-Interoceptive Overload in Frontotemporal Dementia. Agustina Birba, Hernando Santamaría-García, Pavel Prado, Josefina Cruzat, Agustín Sainz Ballesteros, Agustina Legaz, Sol Fittipaldi, Claudia Duran-Aniotz, Andrea Slachevsky, Rodrigo Santibañez, Mariano Sigman, Adolfo M García, Robert Whelan, Sebastián Moguilner, Agustín Ibáñez. Biological Psychiatry 2022 Feb 24;S0006-3223(22)01042-3. DOI: 10.1016/j.biopsych.2022.02.955
  • Population attributable fraction of modifiable risk factors for dementia in Chile. Rodrigo C Vergara, Pedro Zitko, Andrea Slachevsky, Consuelo San Martin, Carolina Delgado. Alzheimers Dement (Amst). 2022 Feb 23;14(1):e12273. DOI: 10.1002/dad2.12273
  • Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs. Alexandra Papaioannou, Federica Centonze, Alice Metais, Marion Maurel, Luc Negroni, Matías Gonzalez-Quiroz, Sayyed Jalil Mahdizadeh, Gabriella Svensson, Ensieh Zare, Alice Blondel, Albert C Koong, Claudio Hetz, Rémy Pedeux, Michel L Tremblay, Leif A Eriksson, Eric Chevet. Life Sci Alliance. 2022 Feb 22;5(5):e202201379. DOI: 10.26508/lsa.202201379
  • Alzheimer’s disease research progress in the Mediterranean region: The Alzheimer’s Association International Conference Satellite Symposium. Claire Sexton, Michele Solis, Judith Aharon-Peretz, Panagiotis Alexopoulos, Liana G Apostolova, Eléonore Bayen, Betty Birkenhager, Stefano Cappa, Fofi Constantinidou, Juan Fortea, Debby L Gerritsen, Hany I Hassanin, Agustin Ibanez, Panagiotis Ioannidis, Elissaios Karageorgiou, Amos Korczyn, Iracema Leroi, Bjorn Lichtwarck, Giancarlo Logroscino, Chris Lynch, Patrizia Mecocci, Jose Luis Molinuevo, John Papatriantafyllou, Sokratis Papegeorgiou, Antonis Politis, Rema Raman, Karen Ritchie, Pascual Sanchez-Juan, Mary Sano, Nikolas Scarmeas, Luiza Spiru, Afroditi Stathi, Magda Tsolaki, Görsev Yener, Ioannis Zaganas, Stelios Zygouris, Maria Carrillo. Alzheimers Dement. 2022 Feb 20. DOI: 10.1002/alz.12588
  • Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease. Denisse Sepúlveda, Marisol Cisternas-Olmedo, Javiera Arcos, Melissa Nassif, René L Vidal. Frontiers in Molecular Neuroscience 2022 Feb 17;15:805087. DOI: 10.3389/fnmol.2022.805087.
  • Editorial: The Unusual Suspects: Linguistic Deficits in Non-Language-Dominant Neurodegenerative Diseases. Adolfo M García, Agustín Ibáñez, Bruce Miller, Maria Luisa Gorno Tempini. Front Aging Neurosci. 2022 Feb 16;14:861041. DOI: 10.3389/fnagi.2022.861041.
  • Multidimensional Clinical Assessment in Frontotemporal Dementia and Its Spectrum in Latin America and the Caribbean: A Narrative Review and a Glance at Future Challenges. Fernando Henríquez, Victoria Cabello, Sandra Baez, Leonardo Cruz de Souza, Patricia Lillo, David Martínez-Pernía, Loreto Olavarría, Teresa Torralva, Andrea Slachevsky. Front Neurol. 2022 Feb 16;12:768591. DOI: 10.3389/fneur.2021.768591
  • Dementia ConnEEGtome: Towards multicentric harmonization of EEG connectivity in neurodegeneration. Pavel Prado, Agustina Birba, Josefina Cruzat, Hernando Santamaría-García, Mario Parra, Sebastian Moguilner, Enzo Tagliazucchi, Agustín Ibáñez. Int J Psychophysiol. 2022 Feb;172:24-38. DOI: 10.1016/j.ijpsycho.2021.12.008
  • Akkermansia muciniphila induces mitochondrial calcium overload and α -synuclein aggregation in an enteroendocrine cell line. Dionísio Pedro Amorim Neto, Beatriz Pelegrini Bosque, João Vitor Pereira de Godoy, Paulla Vieira Rodrigues, Dario Donoso Meneses, Katiane Tostes, Celisa Caldana Costa Tonoli, Hernandes Faustino de Carvalho, Christian González-Billault, Matheus de Castro Fonseca. iScience. 2022 Feb 11;25(3):103908. DOI: 10.1016/j.isci.2022.103908
  • Insulin-like growth factor 2 and autophagy gene expression alteration arise as potential biomarkers in Parkinson’s disease. Denisse Sepúlveda, Felipe Grunenwald, Alvaro Vidal, Paulina Troncoso-Escudero, Marisol Cisternas-Olmedo, Roque Villagra, Pedro Vergara, Carlos Aguilera, Melissa Nassif, Rene L Vidal. Scientific Reports. 2022 Feb 7;12(1):2038. DOI: 10.1038/s41598-022-05941-1

 

ENERO 2022

  • Geometrical characterization of active contraction pulses in epithelial cells using the two-dimensional vertex model. Fernanda Pérez-Verdugo, Germán Reig, Mauricio Cerda, Miguel L Concha, Rodrigo Soto. J R Soc Interface. 2022 Jan;19(186):20210851. DOI: 10.1098/rsif.2021.0851
  • Life-long arsenic exposure damages the microstructure of the rat hippocampus. Sandra A. Nino, Erika Chi-Ahumada, Leticia Carrizales, Ana María Estrada-Sanchez, Christian Gonzalez-Billault, Sergio Zarazúa, Luis Concha, María E. Jimenez-Capdeville. Brain Research. Volume 1775, 15 January 2022, 147742. DOI: 10.1016/j.brainres.2021.147742
  • Automated text-level semantic markers of Alzheimer’s disease. Camila Sanz, Facundo Carrillo, Andrea Slachevsky, Gonzalo Forno, Maria Luisa Gorno Tempini, Roque Villagra, Agustín Ibáñez, Enzo Tagliazucchi, Adolfo M García. Alzheimers Dement (Amst). 2022 Jan 14;14(1):e12276. DOI: 10.1002/dad2.12276 
  • Assays to Study IRE1 Activation and Signaling. Paloma Moraga, Raul Aravena, Hery Urra, Claudio Hetz. Methods Mol Biol. 2022;2378:141-168. DOI: 10.1007/978-1-0716-1732-8_10
  • Apathy, Executive Function, and Emotion Recognition Are the Main Drivers of Functional Impairment in Behavioral Variant of Frontotemporal Dementia. Gada Musa Salech, Patricia Lillo, Karin van der Hiele, Carolina Méndez-Orellana, Agustín Ibáñez, Andrea Slachevsky. Front Neurol. 2022 Jan 13;12:734251. DOI: 10.3389/fneur.2021.734251
  • Validation of Picture Free and Cued Selective Reminding Test for Illiteracy in Lima, Peru. Rosa Montesinos, Jose F Parodi, Monica M Diaz, Eder Herrera-Perez , Elizabeth Valeriano-Lorenzo, Ambar Soto, Carolina Delgado, Andrea Slachevsky, Nilton Custodio. American Journal of Alzheimer’s Disease & Other Dementias Jan-Dec 2022;37:15333175221094396. DOI: 10.1177/15333175221094396.
  • The price of prosociality in pandemic times. Hernando Santamaría-García, Miguel Burgaleta, Agustina Legaz, Daniel Flichtentrei, Mateo Córdoba-Delgado, Juliana Molina-Paredes, Juliana Linares-Puerta, Juan Montealegre-Gómez, Sandra Castelblanco, Michael Schulte, Juan David Páramo, Izara Mondragon, Juan David Leongómez, Paula Salamone, Juan González-Pacheco, Sandra Báez, Harris Eyre & Agustín Ibanez. Humanities and Social Science Communications 9, 15 Jan (2022). DOI: 10.1057/s41599-021-01022-2
  • The Bilingual Lexicon, Back and Forth: Electrophysiological Signatures of Translation Asymmetry. Gonzalo Pérez, Eugenia Hesse, Martín Dottori, Agustina Birba, Lucía Amoruso, Miguel Martorell Caro, Agustín Ibáñez, Adolfo M García. Neuroscience. 2022 Jan 15;481:134-143. DOI: 10.1016/j.neuroscience.2021.11.046
  •  National identity predicts public health support during a global pandemic. Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda, Yusaku Horiuchi, Toan Luu Duc Huynh, Agustin Ibanez, (…). Nature Communications 13, 517 Jan (2022). DOI: 10.1038/s41467-021-27668-9